Shao Si-Yuan, Yang Ya-Nan, Feng Zi-Ming, Jiang Jian-Shuang, Zhang Pei-Cheng
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Bioorg Med Chem Lett. 2019 Oct 1;29(19):126635. doi: 10.1016/j.bmcl.2019.126635. Epub 2019 Aug 23.
Five new phenylpropanoid glycosides, susaroysides A-E (1-5) were isolated from the fruits of Forsythia suspensa. Their structures were elucidated by comprehensive spectroscopic data analysis. The absolute configurations of their sugars were determined by GC analysis. Notably, susaroysides A-D possessed a sugar with an unsubstituted anomeric carbon, which is relatively rare in natural sources. Compound 1 exhibited significant anti-inflammatory activity against the lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α expression in macrophage cells with the IC value of 1.053 μM.
从连翘果实中分离得到了5种新的苯丙素苷，即连翘苷A - E（1 - 5）。通过综合光谱数据分析阐明了它们的结构。通过气相色谱分析确定了其糖的绝对构型。值得注意的是，连翘苷A - D含有一个异头碳未被取代的糖，这在天然来源中相对少见。化合物1对脂多糖（LPS）诱导的巨噬细胞中肿瘤坏死因子（TNF）-α表达具有显著的抗炎活性，IC值为1.053 μM。
