Department of Cardiology, The Second Xiangya Hospital, Central South University, Hunan Province, China.
Department of Cardiology, Asklepios-Klinik St Georg, Hamburg, Germany.
Clin Chim Acta. 2019 Dec;499:4-12. doi: 10.1016/j.cca.2019.08.029. Epub 2019 Aug 29.
Atrial fibrillation (AF) is the most common sustained arrhythmia. Atrial remodeling, including electrical/structural/autonomic remodeling, plays a vital role in AF pathogenesis. All of these have been shown to contribute continuously to the self-perpetuating nature of AF. The Warburg effect was found to play important roles in tumor and non-tumor disease. Recently, lots of studies documented altered atrial metabolism in AF, but the specific mechanism and the impact of these changes upon AF initiation/progression remain unclear. In this article, we review the metabolic consideration in AF comprehensively and observe the footprints of the Warburg effect. We also summarize the signaling pathway involved in the Warburg effect during AF-HIF-1α and AMPK, and discuss their potential roles in AF maintenance and progression. In conclusion, we give the innovative idea that the Warburg effect exists in AF and promotes the progression of AF. Targeting it may provide new therapies for AF treatment.
心房颤动（AF）是最常见的持续性心律失常。心房重构，包括电/结构/自主神经重构，在 AF 的发病机制中起着至关重要的作用。所有这些都被证明有助于 AF 的自我维持特性。沃伯格效应在肿瘤和非肿瘤疾病中发挥着重要作用。最近，大量研究记录了 AF 中心房代谢的改变，但具体的机制以及这些改变对 AF 的起始/进展的影响仍不清楚。在本文中，我们全面综述了 AF 中的代谢考虑因素，并观察到了沃伯格效应的足迹。我们还总结了 AF-HIF-1α 和 AMPK 期间涉及的信号通路，并讨论了它们在 AF 维持和进展中的潜在作用。总之，我们提出了一个创新的观点，即沃伯格效应存在于 AF 中，并促进 AF 的进展。针对它可能为 AF 的治疗提供新的治疗方法。
