Department of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CNB-CSIC), 28049 Madrid, Spain.
Department of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Hans-Knöll-Str. 8, 07745 Jena, Germany.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec;1864(12):158520. doi: 10.1016/j.bbalip.2019.158520. Epub 2019 Aug 29.
Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.
茉莉酸是脂肪酸的衍生物，控制着包括生长、发育和防御在内的几种植物过程。尽管茉莉酸的化学多样性很大，但只有茉莉酰基-L-异亮氨酸（JA-Ile）被明确鉴定为高等植物中茉莉酸共受体（COI1-JAZs）的内源性配体。目前，人们普遍认为 JA-Ile 的 ω-羟化导致分子失活。本研究表明，ω-羟化的 JA-Ile（12-OH-JA-Ile）保留了生物活性，并通过典型的 JA 途径发出信号。结果表明，12-OH-JA-Ile 可差异化地激活一组 JA-Ile 共受体，这些受体可能控制和/或调节特定的茉莉酸依赖反应。有人提出，在 JA-Ile 介导的强烈免疫反应之后，ω-羟化形式调节 JA-Ile 激活的过程，从而提高植物的恢复力。
