Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, #03-06, Immunos Building, Singapore, 138648, Singapore.
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
Mol Diagn Ther. 2019 Dec;23(6):751-760. doi: 10.1007/s40291-019-00423-z.
Psoriasis is a systemic, chronic inflammatory disease that not only afflicts the skin but is also associated with cardiovascular disease and metabolic syndrome. The strongest susceptibility loci for the disease is within the human leukocyte antigen (HLA) complex, though specific HLA allelic associations vary between populations.
Our objective was to investigate HLA associations with clinical phenotypes of psoriasis and metabolic syndrome in Chinese psoriasis cases.
We conducted an observational case-control study in Singapore with a cohort of psoriasis cases consecutively recruited from an outpatient specialist dermatological center (n = 120) compared with 130 healthy controls.
Significant HLA associations with psoriasis were observed with HLA-A02:07, B46:01, C01:02, and C06:02. The three-locus haplotype of A02:07-C01:02-B46:01 was also significant (odds ratio [OR] 3.07; p = 9.47 × 10). We also observed an association between nail psoriasis and HLA-A02:07 carriers (OR 4.50; p = 0.002), whereas C06:02 carriers were less prone to have nail involvement (OR 0.16; p = 0.004). HLA-A02:07 was also identified as a possible risk allele for hypertension (OR 2.90; p < 0.05), and C*01:02 was a possible risk allele for dyslipidemia (OR 3.36; p < 0.05), both known to be common comorbidities in patients with psoriasis.
Our results demonstrate the growing importance of discerning population-specific clinical phenotypes and their association with certain HLA alleles in psoriasis.
银屑病是一种全身性、慢性炎症性疾病，不仅影响皮肤，还与心血管疾病和代谢综合征有关。该疾病的最强易感基因座位于人类白细胞抗原（HLA）复合体中，尽管特定的 HLA 等位基因关联在不同人群之间存在差异。
我们旨在研究 HLA 与中国银屑病患者临床表型和代谢综合征的关联。
我们在新加坡进行了一项观察性病例对照研究，队列由来自皮肤科专家门诊中心的连续招募的银屑病病例（n=120）与 130 名健康对照组成。
观察到与银屑病相关的 HLA 显著关联包括 HLA-A02:07、B46:01、C01:02 和 C06:02。A02:07-C01:02-B46:01 的三个基因座单倍型也具有显著性（比值比 [OR] 3.07；p=9.47×10）。我们还观察到指甲银屑病与 HLA-A02:07 携带者之间存在关联（OR 4.50；p=0.002），而 C06:02 携带者较少出现指甲受累（OR 0.16；p=0.004）。HLA-A02:07 也被确定为高血压的可能风险等位基因（OR 2.90；p<0.05），C*01:02 是血脂异常的可能风险等位基因（OR 3.36；p<0.05），这两种情况都是银屑病患者常见的合并症。
我们的研究结果表明，在银屑病中，区分特定人群的临床表型及其与某些 HLA 等位基因的关联变得越来越重要。
