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从骨折到手术的时间是否会影响髋部骨折患者的死亡率和术中医疗并发症?对挪威髋部骨折登记处报告的 73557 名患者进行的观察性研究。

Does time from fracture to surgery affect mortality and intraoperative medical complications for hip fracture patients? An observational study of 73 557 patients reported to the Norwegian Hip Fracture Register.

机构信息

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

The Norwegian Hip Fracture Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway.

出版信息

Bone Joint J. 2019 Sep;101-B(9):1129-1137. doi: 10.1302/0301-620X.101B9.BJJ-2019-0295.R1.

Abstract

AIMS

The aim of this study was to investigate mortality and risk of intraoperative medical complications depending on delay to hip fracture surgery by using data from the Norwegian Hip Fracture Register (NHFR) and the Norwegian Patient Registry (NPR).

PATIENTS AND METHODS

A total of 83 727 hip fractures were reported to the NHFR between 2008 and 2017. Pathological fractures, unspecified type of fractures or treatment, patients less than 50 years of age, unknown delay to surgery, and delays to surgery of greater than four days were excluded. We studied total delay (fracture to surgery, n = 38 754) and hospital delay (admission to surgery, n = 73 557). Cox regression analyses were performed to calculate relative risks (RRs) adjusted for sex, age, American Society of Anesthesiologists (ASA) classification, type of surgery, and type of fracture. Odds ratio (OR) was calculated for intraoperative medical complications. We compared delays of 12 hours or less, 13 to 24 hours, 25 to 36 hours, 37 to 48 hours, and more than 48 hours.

RESULTS

Mortality remained unchanged when total delay was less than 48 hours. Total delay exceeding 48 hours was associated with increased three-day mortality (RR 1.69, 95% confidence interval (CI) 1.23 to 2.34; p = 0.001) and one-year mortality (RR 1.06, 95% CI 1.04 to 1.22; p = 0.003). More intraoperative medical complications were reported when hospital delay exceeded 24 hours.

CONCLUSION

Hospitals should operate on patients within 48 hours after fracture to reduce mortality and intraoperative complications. Cite this article: 2019;101-B:1129-1137.

摘要

目的

本研究旨在利用挪威髋关节骨折登记处(NHFR)和挪威患者登记处(NPR)的数据,调查因髋部骨折手术延迟而导致的死亡率和术中医疗并发症风险。

患者与方法

2008 年至 2017 年期间,NHFR 共报告了 83727 例髋部骨折。排除病理性骨折、未明确类型的骨折或治疗、年龄小于 50 岁、手术延迟未知以及手术延迟超过 4 天的患者。我们研究了总延迟(骨折至手术,n=38754)和医院延迟(入院至手术,n=73557)。采用 Cox 回归分析计算校正性别、年龄、美国麻醉医师协会(ASA)分级、手术类型和骨折类型后的相对风险(RR)。计算术中医疗并发症的比值比(OR)。我们比较了 12 小时或更短、13 至 24 小时、25 至 36 小时、37 至 48 小时以及超过 48 小时的延迟。

结果

总延迟小于 48 小时时,死亡率保持不变。总延迟超过 48 小时与术后 3 天死亡率增加(RR 1.69,95%置信区间[CI]1.23 至 2.34;p=0.001)和术后 1 年死亡率增加(RR 1.06,95%CI1.04 至 1.22;p=0.003)相关。当医院延迟超过 24 小时时,报告的术中医疗并发症更多。

结论

医院应在骨折后 48 小时内为患者进行手术,以降低死亡率和术中并发症。引用本文:2019;101-B:1129-1137。

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