Kong Tingting, Liu Minghui, Ji Bingyuan, Bai Bo, Cheng Baohua, Wang Chunmei
Cheeloo College of Medicine, Shandong University, Jinan, China.
School of Mental Health, Neurobiology Key Laboratory of Jining Medical University in Colleges of Shandong, Jining Medical University, Jining, China.
Front Physiol. 2019 Aug 14;10:1038. doi: 10.3389/fphys.2019.01038. eCollection 2019.
Extracellular signal-regulated kinase 1/2 (ERK), an important member of the mitogen-activated protein kinase family, is found in many organisms, and it participates in intracellular signal transduction. Various stimuli induce phosphorylation of ERK and . Phosphorylated ERK moves to the nucleus, activates many transcription factors, regulates gene expression, and controls various physiological processes, finally inducing repair processes or cell death. With the aging of the population around the world, the occurrence of ischemia-reperfusion injury (IRI), especially in the brain, heart, kidney, and other important organs, is becoming increasingly serious. Abnormal activation of the ERK signaling pathway is closely related to the development and the metabolic mechanisms of IRI. However, the effects of this signaling pathway and the underlying mechanism differ between various models of IRI. This review summarizes the ERK signaling pathway and the molecular mechanism underlying its role in models of IRI in the brain, heart, liver, kidneys, and other organs. This information will help to deepen the understanding of ERK signals and deepen the exploration of IRI treatment based on the ERK study.
细胞外信号调节激酶1/2（ERK）是丝裂原活化蛋白激酶家族的重要成员，存在于许多生物体中，参与细胞内信号转导。各种刺激可诱导ERK的磷酸化。磷酸化的ERK转移至细胞核，激活多种转录因子，调节基因表达并控制各种生理过程，最终诱导修复过程或细胞死亡。随着全球人口老龄化，缺血再灌注损伤（IRI）的发生率，尤其是在脑、心脏、肾脏等重要器官中的发生率日益严重。ERK信号通路的异常激活与IRI的发生发展及代谢机制密切相关。然而，该信号通路在不同IRI模型中的作用及潜在机制存在差异。本综述总结了ERK信号通路及其在脑、心脏、肝脏、肾脏等器官IRI模型中发挥作用的分子机制。这些信息将有助于加深对ERK信号的理解，并基于ERK研究深化对IRI治疗的探索。
