Wang Feng, Lesser Elizabeth R, Cutsforth-Gregory Jeremy K, Bhatti M Tariq, Kilgore Khin P, Hodge David O, Graff-Radford Jonathan, Petersen Ronald C, Knopman David S, Mielke Michelle M, Lanzino Giuseppe, Leavitt Jaqueline A, Chen John J
Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States.
Health Sciences Research/Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, United States.
Front Neurol. 2019 Aug 16;10:899. doi: 10.3389/fneur.2019.00899. eCollection 2019.
Prior studies evaluating opening pressure (OP) have mostly involved lumbar puncture (LP) for diagnosis of neurologic disease or small cohorts of healthy volunteers and therefore the normal OP is not well-defined. The goal of this study was to establish the normal range of OP in a community-based population using the Mayo Clinic Study of Aging (MCSA) and to evaluate factors that contribute to OP variability. LP OP were obtained from participants aged 32-95 years between 11/1/07 and 10/1/17, as part of routine data collection for the MCSA, a longitudinal, population-based study of residents of Olmsted County, Minnesota. A longitudinal, population-based study of residents of Olmsted County, Minnesota. There were 639 participants (56.8% male; 98.5% white) who underwent LP with recorded OP as part of the MCSA. LP. LP OP was recorded along with variables that could possibly influence its variability, including age, body mass index (BMI), and obstructive sleep apnea (OSA). Six hundred thirty-nine participants (56.8% men) underwent LP with recorded OP; average age was 71.0 years (SD 10.9) with a mean BMI of 28.0 (SD 4.6). Mean OP was 155.4 mmHO (SD 41.9) with a 95% reference interval of 82-242 mmHO (range 60-314; Q1, Q3: 124, 182). Increasing age was associated with lower OP ( < 0.001), while increasing BMI was associated with higher OP ( < 0.001). Twelve (2%) participants had OP ≥ 250 mmHO; they were younger [58.5 (SD 8.2), < 0.001], had higher BMI [33.6 (SD 4.6), < 0.001], and were more likely to have OSA (75%, < 0.001). Among the 79 participants with repeat LPs within 2.5 years, the coefficient of repeatability (CR) was 64.9. Ten (12.7%) had an OP difference ≥50 mmHO between serial LPs. This large population-based study showed that LP OP can vary significantly among individuals. Higher OPs were associated with higher BMI and younger age.
先前评估初压（OP）的研究大多涉及为诊断神经疾病而进行的腰椎穿刺（LP），或是针对一小群健康志愿者，因此正常OP尚未明确界定。本研究的目的是利用梅奥诊所衰老研究（MCSA）确定社区人群中OP的正常范围，并评估导致OP变异性的因素。作为MCSA常规数据收集的一部分，于2007年11月1日至2017年10月1日期间从32至95岁的参与者中获取LP OP，MCSA是一项针对明尼苏达州奥尔姆斯特德县居民的纵向、基于人群的研究。对明尼苏达州奥尔姆斯特德县居民进行的一项纵向、基于人群的研究。有639名参与者（56.8%为男性；98.5%为白人）作为MCSA的一部分接受了记录有OP的LP。LP。记录LP OP以及可能影响其变异性的变量，包括年龄、体重指数（BMI）和阻塞性睡眠呼吸暂停（OSA）。639名参与者（56.8%为男性）接受了记录有OP的LP；平均年龄为71.0岁（标准差10.9），平均BMI为28.0（标准差4.6）。平均OP为155.4 mmHO（标准差41.9），95%参考区间为82 - 242 mmHO（范围60 - 314；第一四分位数、第三四分位数：124, 182）。年龄增加与较低的OP相关（<0.001），而BMI增加与较高的OP相关（<0.001）。12名（2%）参与者的OP≥250 mmHO；他们更年轻[58.5（标准差8.2），<0.001]，BMI更高[33.6（标准差4.6），<0.001]，且更有可能患有OSA（75%，<0.001）。在2.5年内进行重复LP的79名参与者中，重复性系数（CR）为64.9。10名（12.7%）参与者连续两次LP之间的OP差值≥50 mmHO。这项基于大量人群的研究表明，LP OP在个体之间可能有显著差异。较高的OP与较高的BMI和较年轻的年龄相关。
