定量剪切波弹性成像用于无创评估实性胰腺肿块。

Quantitative shear wave elastography for noninvasive assessment of solid pancreatic masses.

机构信息

Department of Medical Ultrasound, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

出版信息

Clin Hemorheol Microcirc. 2020;74(2):179-187. doi: 10.3233/CH-190665.

DOI:10.3233/CH-190665

PMID:31476148

Abstract

PURPOSE

To evaluate the diagnostic value of quantitative shear wave elastography (SWE) for the differential diagnosis of solid pancreatic tumors.

MATERIALS AND METHODS

A total of 66 solid pancreatic masses were enrolled in this study and all the lesions underwent quantitative SWE. The stiffness of the masses was expressed in shear wave velocity (SWV, m/s). The receiver operating characteristic (ROC) curve was plotted to assess the diagnostic performance of quantitative SWE. The optimal cutoff value for SWV in the differentiation of benign from malignant masses was determined.

RESULTS

The final diagnoses were 26 benign and 40 malignant masses. The SWVs were statistically higher for pancreatic malignant masses compared with those for benign masses (3.30±1.22 m/s versus 1.31±0.64 m/s; P < 0.001). The area under the curve (AUC, 0.93) was obtained. When the best cut-off point was 1.77 m/s, the accuracy, sensitivity, and specificity were 92.4%, 90.0%, and 96.2%, respectively.

CONCLUSIONS

Quantitative SWE is a novel technique that can be considered as a quantitative and objective diagnostic tool for prediction of pancreas malignancy.

摘要

目的

评估定量剪切波弹性成像（SWE）在鉴别诊断实性胰腺肿瘤中的诊断价值。

材料与方法

本研究共纳入 66 例实性胰腺肿块，所有病灶均行定量 SWE 检查。肿块的硬度以剪切波速度（SWV，m/s）表示。绘制受试者工作特征（ROC）曲线评估定量 SWE 的诊断性能。确定 SWV 在鉴别良恶性肿块的最佳截断值。

结果

最终诊断为 26 例良性和 40 例恶性肿块。与良性肿块相比，胰腺恶性肿块的 SWV 明显更高（3.30±1.22 m/s 比 1.31±0.64 m/s；P<0.001）。曲线下面积（AUC，0.93）。当最佳截断点为 1.77 m/s 时，其准确性、敏感性和特异性分别为 92.4%、90.0%和 96.2%。