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2018 年哮喘、哮喘-COPD 重叠和相关生物制剂的研究进展。

Advances in asthma, asthma-COPD overlap, and related biologics in 2018.

机构信息

Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.

Department of Advanced Medicine, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.

出版信息

J Allergy Clin Immunol. 2019 Oct;144(4):906-919. doi: 10.1016/j.jaci.2019.08.021. Epub 2019 Aug 30.

Abstract

Over the past year, numerous important advances in our understanding of multiple aspects of asthma, ranging from disease pathogenesis to epidemiology to therapeutics, have been reported. This review is a compilation of highlights from articles published largely in the Journal of Allergy and Clinical Immunology and supplemented by articles published elsewhere that have substantially advanced the fields of asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap and biologic therapies for these disorders. The intention of this article is not to provide a comprehensive review but rather to focus on several areas that have developed quickly and/or received extensive attention from our readers.

摘要

在过去的一年中,我们对哮喘的多个方面的认识取得了许多重要进展,涵盖了从疾病发病机制到流行病学再到治疗学等多个领域。这篇综述是对主要发表在《过敏与临床免疫学杂志》上的文章的精选,同时补充了其他地方发表的、对哮喘、慢性阻塞性肺疾病(COPD)、哮喘-COPD 重叠以及这些疾病的生物治疗领域有重要推动作用的文章。本文的目的不是提供全面的综述,而是重点关注几个快速发展的领域和/或受到读者广泛关注的领域。

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