Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Department of Sociobehavioral and Administrative Pharmacy, College of Pharmacy, Nova Southeastern University, Davie, FL, USA.
Department of Sociobehavioral and Administrative Pharmacy, College of Pharmacy, Nova Southeastern University, Davie, FL, USA.
Thromb Res. 2019 Oct;182:110-115. doi: 10.1016/j.thromres.2019.08.013. Epub 2019 Aug 19.
Cancer patients are prone to higher risk of venous thromboembolism (VTE) compared to the general population. However, the estimated incidence of cancer-associated VTE varied among the studies. The primary objective of this study was to determine the national annual incidence and examine the trend of cancer-associated VTE in the US over the years from 2005 to 2014.
A retrospective population based study was conducted using data from the Medical Expenditure Panel Survey. The study included all noninstitutionalized US adults aged ≥18 years who had a final person-weight > 0 to be representative of the national population. Simple linear regression (SLR) and Mann-Kendall (MK) tests were used to examine the trend of cancer-associated VTE over the years.
On average, there were 15,570,000 adult persons living with a cancer condition every year. Female represented 53.8% of the study population, and the mean of age was 63.5 years. The overall annual incidence of cancer-associated VTE varied between 1.80 and 0.72% over the years, with an overall average of 1.18%. The study found a non-significant downward trend in the incidence of cancer-associated VTE over the years. Patients who had cancer-associated VTE were significantly older than patients without VTE (mean 68.64 vs. 62.68 years, p < .0001).
The study found cancer patients continued to have the risk of VTE over the years. The non-significant downward trend in cancer-associated VTE suggests that health care practitioners are heading in the right direction, but enhanced preventative care is needed to avoid further incidents of cancer-associated VTE.
与普通人群相比，癌症患者更容易发生静脉血栓栓塞症（VTE）。然而，各研究中癌症相关 VTE 的估计发生率存在差异。本研究的主要目的是确定美国癌症相关 VTE 的全国年度发病率，并在 2005 年至 2014 年期间逐年检查其趋势。
使用医疗支出面板调查的数据进行回顾性人群研究。该研究包括所有非住院的≥18 岁美国成年人，其最终个人体重>0 以代表全国人口。简单线性回归（SLR）和曼肯德尔（MK）检验用于检查多年来癌症相关 VTE 的趋势。
平均而言，每年有 1557 万患有癌症的成年患者。女性占研究人群的 53.8%，平均年龄为 63.5 岁。多年来，癌症相关 VTE 的总体年发病率在 1.80%和 0.72%之间变化，总体平均为 1.18%。研究发现，多年来癌症相关 VTE 的发病率呈非显著下降趋势。患有癌症相关 VTE 的患者明显比没有 VTE 的患者年龄大（平均 68.64 岁比 62.68 岁，p<0.0001）。
本研究发现癌症患者多年来仍有发生 VTE 的风险。癌症相关 VTE 的非显著下降趋势表明医疗保健从业者正在朝着正确的方向前进，但需要加强预防保健以避免进一步发生癌症相关 VTE。
