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在小肠透析的单个平滑肌细胞中，毒蕈碱受体刺激诱发的内向电流涉及一种钙依赖性机制，而非G蛋白机制。

A calcium-dependent rather than a G-protein mechanism is involved in the inward current evoked by muscarinic receptor stimulation in dialysed single smooth muscle cells of small intestine.

作者信息

Lim S P, Bolton T B

机构信息

Department of Pharmacology, St George's Hospital Medical School, London.

出版信息

Br J Pharmacol. 1988 Oct;95(2):325-7. doi: 10.1111/j.1476-5381.1988.tb11649.x.

DOI:10.1111/j.1476-5381.1988.tb11649.x
PMID:3147801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1854166/
Abstract

A role of internal calcium was found in the inward current response of single, dispersed, smooth muscle cells to muscarinic receptor activation but no obligatory role for guanine nucleotide binding proteins, in contrast to their obligatory role in muscarinic responses in heart and other tissues.

摘要

在单个分散的平滑肌细胞对毒蕈碱受体激活的内向电流反应中发现了细胞内钙的作用，但鸟嘌呤核苷酸结合蛋白没有必然作用，这与它们在心脏和其他组织的毒蕈碱反应中的必然作用形成对比。

相似文献

1
A calcium-dependent rather than a G-protein mechanism is involved in the inward current evoked by muscarinic receptor stimulation in dialysed single smooth muscle cells of small intestine.在小肠透析的单个平滑肌细胞中，毒蕈碱受体刺激诱发的内向电流涉及一种钙依赖性机制，而非G蛋白机制。
Br J Pharmacol. 1988 Oct;95(2):325-7. doi: 10.1111/j.1476-5381.1988.tb11649.x.
2
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3
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4
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Action of acetylcholine on smooth muscle.乙酰胆碱对平滑肌的作用。
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Inhibitory effect of muscarinic receptor activation on Ca2+ channel current in smooth muscle cells of guinea-pig ileum.毒蕈碱受体激活对豚鼠回肠平滑肌细胞钙通道电流的抑制作用。
J Physiol. 1995 May 1;484 ( Pt 3)(Pt 3):567-81. doi: 10.1113/jphysiol.1995.sp020687.
4
Effects of high-energy phosphates on carbachol-evoked cationic current in single smooth muscle cells from guinea-pig ileum.高能磷酸盐对豚鼠回肠单个平滑肌细胞中卡巴胆碱诱发的阳离子电流的影响。
J Physiol. 1995 Jun 15;485 ( Pt 3)(Pt 3):659-69. doi: 10.1113/jphysiol.1995.sp020760.
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Properties of calcium stores and transient outward currents in single smooth muscle cells of rabbit intestine.兔肠单个平滑肌细胞中钙储存和瞬时外向电流的特性
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Muscarinic receptor is coupled with a cation channel through a GTP-binding protein in guinea-pig chromaffin cells.在豚鼠嗜铬细胞中，毒蕈碱受体通过一种GTP结合蛋白与阳离子通道偶联。
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本文引用的文献

1
Potentiation of muscarinic and alpha-adrenergic responses by an analogue of guanosine 5'-triphosphate.鸟苷 5'-三磷酸类似物对毒蕈碱和α-肾上腺素能反应的增强作用。
Proc Natl Acad Sci U S A. 1986 Jun;83(11):4099-103. doi: 10.1073/pnas.83.11.4099.
2
Dependence on Ca2+ of the activities of phosphatidylinositol 4,5-bisphosphate phosphodiesterase and inositol 1,4,5-trisphosphate phosphatase in smooth muscles of the porcine coronary artery.猪冠状动脉平滑肌中磷脂酰肌醇4,5-二磷酸磷酸二酯酶和肌醇1,4,5-三磷酸磷酸酶活性对Ca2+的依赖性。
Biochem J. 1985 Nov 1;231(3):497-503. doi: 10.1042/bj2310497.
3
Somatostatin increases an inwardly rectifying potassium conductance in guinea-pig submucous plexus neurones.生长抑素可增加豚鼠黏膜下神经丛神经元的内向整流钾电导。
J Physiol. 1987 Sep;390:335-55. doi: 10.1113/jphysiol.1987.sp016704.
4
Short-term desensitization of muscarinic K+ channel current in isolated atrial myocytes and possible role of GTP-binding proteins.离体心房肌细胞毒蕈碱钾通道电流的短期脱敏及GTP结合蛋白的可能作用
Pflugers Arch. 1987 Oct;410(3):227-33. doi: 10.1007/BF00580270.
5
Acetylcholine activates single sodium channels in smooth muscle cells.乙酰胆碱激活平滑肌细胞中的单个钠通道。
Pflugers Arch. 1987 Sep;410(1-2):69-74. doi: 10.1007/BF00581898.
6
Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit.兔单个内脏和血管平滑肌细胞中的自发性瞬时外向电流。
J Physiol. 1986 Dec;381:385-406. doi: 10.1113/jphysiol.1986.sp016333.
7
The alpha subunit of the GTP binding protein Gk opens atrial potassium channels.GTP结合蛋白Gk的α亚基可开启心房钾通道。
Science. 1987 Apr 24;236(4800):442-5. doi: 10.1126/science.2436299.
8
Uncoupling of cardiac muscarinic and beta-adrenergic receptors from ion channels by a guanine nucleotide analogue.一种鸟嘌呤核苷酸类似物使心肌毒蕈碱受体和β-肾上腺素能受体与离子通道解偶联。
Nature. 1985;317(6037):538-40. doi: 10.1038/317538a0.
9
Acetylcholine activates an inward current in single mammalian smooth muscle cells.乙酰胆碱可激活单个哺乳动物平滑肌细胞中的内向电流。
Nature. 1985;316(6026):345-7. doi: 10.1038/316345a0.
10
GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists.毒蕈碱型胆碱能激动剂对心脏腺苷酸环化酶的GTP依赖性抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1979 Dec;310(2):113-9. doi: 10.1007/BF00500275.