在小肠透析的单个平滑肌细胞中，毒蕈碱受体刺激诱发的内向电流涉及一种钙依赖性机制，而非G蛋白机制。
A calcium-dependent rather than a G-protein mechanism is involved in the inward current evoked by muscarinic receptor stimulation in dialysed single smooth muscle cells of small intestine.
作者信息
Lim S P, Bolton T B
机构信息
Department of Pharmacology, St George's Hospital Medical School, London.
出版信息
Br J Pharmacol. 1988 Oct;95(2):325-7. doi: 10.1111/j.1476-5381.1988.tb11649.x.
Abstract
A role of internal calcium was found in the inward current response of single, dispersed, smooth muscle cells to muscarinic receptor activation but no obligatory role for guanine nucleotide binding proteins, in contrast to their obligatory role in muscarinic responses in heart and other tissues.
摘要
在单个分散的平滑肌细胞对毒蕈碱受体激活的内向电流反应中发现了细胞内钙的作用，但鸟嘌呤核苷酸结合蛋白没有必然作用，这与它们在心脏和其他组织的毒蕈碱反应中的必然作用形成对比。
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