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大鼠离体肠系膜上动脉床中内皮依赖性对精氨酸加压素升压活性的调节

Endothelium-dependent modulation of the pressor activity of arginine vasopressin in the isolated superior mesenteric arterial bed of the rat.

作者信息

Randall M D, Kay A P, Hiley C R

机构信息

Department of Pharmacology, University of Cambridge.

出版信息

Br J Pharmacol. 1988 Oct;95(2):646-52. doi: 10.1111/j.1476-5381.1988.tb11687.x.

DOI:10.1111/j.1476-5381.1988.tb11687.x
PMID:3147805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1854167/
Abstract
  1. Pressor responses to arginine vasopressin (AVP) were determined in the rat isolated superior mesenteric arterial bed perfused with Krebs-Henseleit solution and compared with those to noradrenaline. 2. In control preparations the maximum pressor response to the peptide was 34 +/- 3 mmHg and the ED50 was 21 +/- 4 mu (n = 11). The maximal pressor response to noradrenaline (30 micrograms) was 100 +/- 6 mmHg (n = 8). After removal of the functional endothelium with the detergent CHAPS, the maximum pressor response to AVP increased to 64 +/- 4 mmHg and the ED50 decreased to 7.7 +/- 2.0 mu (n = 11) but the response to 10 micrograms noradrenaline was unaffected. 3. Nordihydroguaiaretic acid (2.5 microM) significantly increased the maximum pressor response to AVP from 41 +/- 2 mmHg to 86 +/- 8 mmHg (n = 9); the ED50 was unchanged. Methylene blue (50 microM) also increased the maximum response from 41 +/- 3 mmHg to 87 +/- 13 mmHg (n = 8) without affecting the ED50. Neither treatment significantly affected the response to 10 micrograms noradrenaline. 4. Neither indomethacin (10 microM) nor BW755C (10 microM) had significant effects upon either the maximal response or ED50 for AVP nor did they affect the response to 10 micrograms noradrenaline. 5. In 6 preparations SKF-525A significantly increased both the ED50, from 9.8 +/- 2.1 to 22 +/- 2 mu, and the maximum response, from 36 +/- 2 to 70 +/- 3 mmHg. 6. It is concluded that the pressor response to AVP in this vascular bed is modulated, in the presence of functional endothelium, by the simultaneous release of endothelium-derived relaxing factor.
摘要
  1. 在灌注克氏-亨氏溶液的大鼠离体肠系膜上动脉床中测定了对精氨酸加压素（AVP）的升压反应，并与对去甲肾上腺素的升压反应进行了比较。2. 在对照制剂中，对该肽的最大升压反应为34±3 mmHg，半数有效剂量（ED50）为21±4 μ（n = 11）。对去甲肾上腺素（30微克）的最大升压反应为100±6 mmHg（n = 8）。用去污剂CHAPS去除功能性内皮后，对AVP的最大升压反应增加到64±4 mmHg，ED50降低到7.7±2.0 μ（n = 11），但对10微克去甲肾上腺素的反应未受影响。3. 去甲二氢愈创木酸（2.5微摩尔）显著增加了对AVP的最大升压反应，从41±2 mmHg增加到86±8 mmHg（n = 9）；ED50未改变。亚甲蓝（50微摩尔）也将最大反应从41±3 mmHg增加到87±13 mmHg（n = 8），而不影响ED50。两种处理均未显著影响对10微克去甲肾上腺素的反应。4. 吲哚美辛（10微摩尔）和BW755C（10微摩尔）对AVP的最大反应或ED50均无显著影响，也不影响对10微克去甲肾上腺素的反应。5. 在6个制剂中，SKF-525A显著增加了ED50，从9.8±

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