Tong Ying-Hui, He Ying, Hu Lu-Ying, Liu Yu-Jia, Zheng Xiao-Wei, Sun Jiao, Song Yu, Zhang Yi-Wen, Fang Luo, Huang Ping
Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, China.
Department of Pharmacy, Children's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Tumori. 2019 Dec;105(6):494-500. doi: 10.1177/0300891619871103. Epub 2019 Sep 3.
An integral and well-functioning vascular system is essential for tumor progression and chemotherapy infusion. However, the lumen integrity of the microvessels and its significance in prognosis has not been studied. In this study, we found that the proportion of collapsed microvessels is suggested to be a novel biomarker for predicting prognosis in patients with non-small cell lung cancer (NSCLC).
In this study, immunohistochemical CD31 staining was performed to identify the microvessels in tumor specimens. Proportions of collapsed vessels were estimated in CD31-stained tumor specimens from 100 patients with NSCLC. The correlation between collapsed microvessel proportion and survival time were evaluated by univariate and multivariate analysis.
Data from 99 patients were analyzed and a wide range of collapse-microvessel fraction was observed in 96 patients (1.4%-70%). Elevated collapse proportion (⩾6.5%) indicated poor overall survival in both univariate analysis ( = 0.042) and multivariate analysis ( = 0.014).
Elevated proportion of collapsed microvessels indicted poor survival outcome in patients with NSCLC.
完整且功能良好的血管系统对于肿瘤进展和化疗药物输注至关重要。然而，微血管的管腔完整性及其在预后中的意义尚未得到研究。在本研究中，我们发现塌陷微血管的比例有望成为预测非小细胞肺癌（NSCLC）患者预后的一种新型生物标志物。
在本研究中，采用免疫组织化学CD31染色来识别肿瘤标本中的微血管。对100例NSCLC患者的CD31染色肿瘤标本中塌陷血管的比例进行评估。通过单因素和多因素分析评估塌陷微血管比例与生存时间之间的相关性。
分析了99例患者的数据，96例患者（1.4%-70%）的塌陷微血管比例范围较广。在单因素分析（P = 0.042）和多因素分析（P = 0.014）中，塌陷比例升高（⩾6.5%）均提示总生存期较差。
塌陷微血管比例升高表明NSCLC患者的生存结局较差。
