Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab-, 140306, India.
Chem Asian J. 2019 Dec 13;14(24):4688-4695. doi: 10.1002/asia.201900960. Epub 2019 Sep 24.
A sequential two-step method for the synthesis of hetero-arylated triarylmethanes through a Ag-catalyzed sequential double cyclization-nucleophilic addition cascade is described. This methodology basically involves an initial 5-endo-dig cyclization of o-alkynyl anilines to provide 2-substituted indole derivatives, which then react with 2-(2-enynyl)-pyridines to afford indolizine-containing unsymmetrical triarylmethanes through another 5-endo-dig cyclization.
本文描述了一种通过 Ag 催化的顺序双环化-亲核加成级联反应合成杂芳基三芳基甲烷的两步顺序方法。该方法基本上包括 o-炔基苯胺的初始 5-endo-环化，以提供 2-取代吲哚衍生物，然后与 2-(2-烯基)吡啶反应，通过另一个 5-endo-环化反应得到含吲哚嗪的不对称三芳基甲烷。
