Department of Kinesiology and Physical Education, McGill University, Montréal, Canada; Integrated Program in Neuroscience, McGill University, Montréal, Canada; Centre for Interdisciplinary Research in Rehabilitation, Montréal, Canada.
Department of Kinesiology and Physical Education, McGill University, Montréal, Canada; Centre for Interdisciplinary Research in Rehabilitation, Montréal, Canada.
Neuroscience. 2019 Oct 15;418:311-317. doi: 10.1016/j.neuroscience.2019.08.042. Epub 2019 Aug 31.
Freezing of gait (FOG) is a common motor symptom in Parkinson's disease (PD) thought to arise from the dysfunctional cortico-basal ganglia-thalamic circuity. The purpose of this study was to assess the changes in brain resting-state functional connectivity (rs-FC) of subcortical structures comprising the cortico-basal ganglia-thalamic circuity in individuals with PD with and without FOG. Resting-state functional magnetic resonance imaging was acquired in 27 individuals with idiopathic PD (14 with FOG and 13 without FOG). A seed-to-voxel analysis was performed with the seeds in the bilateral basal ganglia nuclei, thalamus, and pedunculopontine nucleus. Between-group differences in rs-FC revealed that the bilateral thalamus and globus pallidus external were significantly more connected with visual areas in PD with FOG compared to PD without FOG. In addition, PD with FOG had increased connectivity between the left putamen and retrosplenial cortex as well as with the cerebellum. Our findings suggest an increased connectivity at rest of subcortical and cortical regions involved in sensory and visuospatial processing that may be compensating for sensorimotor deficits in FOG. This increased connectivity may contribute to the hypothesized overload in the cortico-basal ganglia-thalamic circuity processing capacity, which may ultimately result in FOG occurrence.
冻结步态（FOG）是帕金森病（PD）的一种常见运动症状，被认为源于皮质基底节丘脑回路的功能障碍。本研究旨在评估伴有和不伴有 FOG 的 PD 患者皮质基底节丘脑回路亚结构的脑静息状态功能连接（rs-FC）的变化。对 27 名特发性 PD 患者（14 名有 FOG，13 名无 FOG）进行了静息状态功能磁共振成像。采用双侧基底节核、丘脑和脑桥被盖核作为种子点进行种子到体素分析。rs-FC 的组间差异显示，与无 FOG 的 PD 相比，FOG 的 PD 双侧丘脑和苍白球外部与视觉区域的连接明显增加。此外，FOG 的 PD 患者左侧壳核与后扣带回皮质以及与小脑之间的连接增加。我们的研究结果表明，与感觉和视空间处理相关的皮质下和皮质区域的静息状态连接增加，这可能是对 FOG 中运动感觉缺陷的一种代偿。这种增加的连接可能有助于假设的皮质基底节丘脑回路处理能力过载，这可能最终导致 FOG 的发生。
