Cleto-Zepeda G, Durán-Martínez N, Tena-Sanabria M E
Hospital General Xoco, Mexico City.
Orthopedics and Traumatology Department of the Centro Medico Dalinde, Mexico City.
Acta Ortop Mex. 2019 Jan-Feb;33(1):39-41.
Bisphosphonates have been the gold standard in the management of osteoporosis. Its antiresorptive effect has reduced the incidence of fractures due to bone fragility, as well as its impact on public health. We present the clinical case of a patient in prolonged treatment with bisphosphonates and atypical bilateral femur fracture.
A 65-year-old female who presented a fall from her own height, on treatment with risedronate for seven years, and a history of systemic arterial hypertension and hypercholesterolemia, both with medical treatment. Diagnosed with bilateral atypical femoral fracture, treated with closed reduction internal fixation (CRIF) with intramedullary nailing, application of calcium citrate and teriparatide.
Multiple studies indicate that the benefit of using bisphosphonates for osteoporosis is higher than the risk of presenting atypical fractures.
双膦酸盐一直是骨质疏松症治疗的金标准。其抗吸收作用降低了因骨脆性导致的骨折发生率及其对公共卫生的影响。我们报告一例长期接受双膦酸盐治疗并发生非典型双侧股骨骨折的患者的临床病例。
一名65岁女性,因自行摔倒前来就诊,已接受利塞膦酸盐治疗七年,有系统性动脉高血压和高胆固醇血症病史,均接受药物治疗。诊断为双侧非典型股骨骨折,采用髓内钉闭合复位内固定(CRIF)治疗,并应用柠檬酸钙和特立帕肽。
多项研究表明,使用双膦酸盐治疗骨质疏松症的益处高于发生非典型骨折的风险。