新兴的蛋白质组学研究有助于深入了解蜜蜂的生物学。
The Emerging Proteomic Research Facilitates in-Depth Understanding of the Biology of Honeybees.
机构信息
Institute of Apicultural Research/Key Laboratory of Pollinating Insect Biology, Ministry of Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Agricultural Information Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
出版信息
Int J Mol Sci. 2019 Aug 30;20(17):4252. doi: 10.3390/ijms20174252.
Advances in instrumentation and computational analysis in proteomics have opened new doors for honeybee biological research at the molecular and biochemical levels. Proteomics has greatly expanded the understanding of honeybee biology since its introduction in 2005, through which key signaling pathways and proteins that drive honeybee development and behavioral physiology have been identified. This is critical for downstream mechanistic investigation by knocking a gene down/out or overexpressing it and being able to attribute a specific phenotype/biochemical change to that gene. Here, we review how emerging proteome research has contributed to the new understanding of honeybee biology. A systematic and comprehensive analysis of global scientific progress in honeybee proteome research is essential for a better understanding of research topics and trends, and is potentially useful for future research directions.
仪器和计算分析在蛋白质组学方面的进步为蜜蜂的分子和生化水平的生物学研究开辟了新的途径。自 2005 年引入蛋白质组学以来，它极大地扩展了对蜜蜂生物学的理解，通过它确定了驱动蜜蜂发育和行为生理学的关键信号通路和蛋白质。这对于通过敲除/过表达一个基因并能够将特定的表型/生化变化归因于该基因来进行下游的机制研究至关重要。在这里，我们回顾了新兴的蛋白质组学研究如何促进对蜜蜂生物学的新认识。对蜜蜂蛋白质组研究全球科学进展进行系统和全面的分析，对于更好地理解研究课题和趋势至关重要，并且对于未来的研究方向可能是有用的。
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