Favin F D, Klein-Schwartz W, Oderda G M, Rose S R
Maryland Poison Center, University of Maryland, School of Pharmacy, Baltimore 21201.
J Toxicol Clin Toxicol. 1988;26(7):443-50. doi: 10.3109/15563658809038560.
The purpose of this study was to determine whether lithium carbonate (Li2CO3) is effectively adsorbed by activated charcoal (AC). Either 0 (control), 1.5, 3.0 or 9.0 grams of AC were added to Li2CO3 (300 mg) in distilled deionized water or simulated gastric fluid USP, filtered and and the filtrate analyzed for lithium by flame photometry. Adsorption of lithium was dependent on AC concentration and pH. In water, lithium was 14.7%, 26.5% and 40.4% adsorbed at AC:Li2CO3 ratios of 5:1, 10:1 and 30:1, respectively (p less than 0.05). In simulated gastric fluid, there was no significant adsorption at any of the AC concentrations studied. Since simulated gastric fluid more closely resembles in vivo conditions, the efficacy of AC in lithium carbonate overdoses is questionable but in vivo studies are needed to confirm these findings.
本研究的目的是确定碳酸锂（Li2CO3）是否能被活性炭（AC）有效吸附。将0克（对照）、1.5克、3.0克或9.0克活性炭添加到蒸馏去离子水或模拟胃液USP中的碳酸锂（300毫克）中，过滤后，通过火焰光度法分析滤液中的锂。锂的吸附取决于活性炭浓度和pH值。在水中，当活性炭与碳酸锂的比例为5:1、10:1和30:1时，锂的吸附率分别为14.7%、26.5%和40.4%（p小于0.05）。在模拟胃液中，在所研究的任何活性炭浓度下均无显著吸附。由于模拟胃液更接近体内情况，活性炭在碳酸锂过量服用中的疗效值得怀疑，但需要进行体内研究来证实这些发现。
