Department of Surgery and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.
Cancer Discov. 2019 Sep;9(9):1164-1166. doi: 10.1158/2159-8290.CD-19-0722.
Unlike conventional MHC-reactive T cells, unconventional T cells have emerged as an abundant component of the human immune system because of their role in tumor immunology. In this issue of , Hundeyin and colleagues have identified a population of unconventional T cells in pancreatic tumors that can reprogram the immune evasive components of the tumor to promote immunogenicity and thus are critical for the development of novel cell-based therapy in pancreatic cancer..
与传统的 MHC 反应性 T 细胞不同，由于其在肿瘤免疫学中的作用，非传统 T 细胞已成为人体免疫系统的丰富组成部分。在本期的 中，Hundeyin 及其同事在胰腺肿瘤中鉴定出了一类非传统 T 细胞，它们可以重新编程肿瘤的免疫逃避成分，以促进免疫原性，因此对于开发胰腺癌的新型基于细胞的治疗方法至关重要。
