Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Japan.
J Hum Hypertens. 2020 Feb;34(2):125-131. doi: 10.1038/s41371-019-0230-y. Epub 2019 Sep 3.
The aim of this study is to show the combined effect of weight gain within normal weight range in adulthood and parental HT on the prevalence of HT. The study subjects were 44,998 individuals (19,039 men and 25,959 women) with normal weight (body mass index [BMI] 18.5-24.9) aged 35-69 years who participated in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were categorized into six groups by weight gain from age 20 years (<10 kg, and ≥10 kg) and by the number of parents having HT (no parent, one parent, and both parents). Odds ratios for HT were estimated after adjustment for age, sex, current BMI, estimated daily sodium intake, and other confounding factors. The prevalence of HT (31.5% in total subjects) gradually increased with greater weight gain from age 20 years and with greater number of parents with HT. Subjects who gained weight ≥10 kg and having both parents with HT showed the highest risk of having HT compared with those who gained weight <10 kg without parental HT (59.8% vs. 24.9%, odds ratio 4.25, 95% CI 3.53-5.13 after adjustment). This association was similarly observed in any category of age, sex, and BMI. Subjects who gained weight within normal range of BMI and having one or both parent(s) with HT showed the higher risk of having HT independent of their attained BMI in their middle ages. Thus, subjects having parent(s) with HT should avoid gaining their weight during adulthood, even within normal range of BMI, to reduce the risk of having HT.
本研究旨在探讨成年后体重正常范围内的体重增加和父母高血压（HT）对 HT 患病率的综合影响。研究对象为 44998 名体重正常（体重指数 [BMI] 18.5-24.9）、年龄 35-69 岁的成年人，他们参加了日本多机构合作队列研究（J-MICC 研究）。根据 20 岁时体重增加（<10kg 和≥10kg）和父母 HT 数量（无父母、一方父母和双方父母）将他们分为六组。在校正年龄、性别、当前 BMI、估计的每日钠摄入量和其他混杂因素后，估计 HT 的比值比。HT 的患病率（总人群中为 31.5%）随 20 岁时体重增加和父母 HT 数量的增加而逐渐升高。与体重增加<10kg 且无父母 HT 的人群相比，体重增加≥10kg 且父母均有 HT 的人群发生 HT 的风险最高（59.8% vs. 24.9%，调整后比值比 4.25，95%CI 3.53-5.13）。这种关联在任何年龄、性别和 BMI 类别中均观察到。在 BMI 正常范围内体重增加且一方或双方父母有 HT 的人群，即使在中年时达到 BMI 正常范围，也有发生 HT 的更高风险，这独立于他们的 BMI。因此，即使在 BMI 正常范围内，有 HT 父母的人群也应避免在成年后增加体重，以降低 HT 的风险。
