Almeida Filipe, Albuquerque Elisabete, Murta Ilda
Department of Psychiatry, The Coimbra Hospital and University Centre, Coimbra, Portugal.
Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Front Neurosci. 2019 Aug 20;13:886. doi: 10.3389/fnins.2019.00886. eCollection 2019.
Quetiapine in an atypical antipsychotic drug that is frequently used for delirium and behavioral and psychological symptoms in dementia. However, its potential anticholinergic effects, mediated primarily through its metabolite norquetiapine, could present as counterproductive adverse effects in these situations. There is little data published discussing this potential negative impact on quetiapine's safety and tolerability, especially in the elderly. Here, we present what is, to our knowledge, the first published case report of delirium apparently induced by low-dose quetiapine, in a 95-year-old patient with no prior history of mental illness, and the potential role of its metabolite norquetiapine.
喹硫平是一种非典型抗精神病药物，常用于治疗谵妄以及痴呆患者的行为和心理症状。然而，其主要通过代谢产物去甲喹硫平介导的潜在抗胆碱能作用，在这些情况下可能会产生适得其反的不良反应。关于这种对喹硫平安全性和耐受性的潜在负面影响，尤其是在老年人中的相关数据很少。在此，据我们所知，我们呈现了首例关于低剂量喹硫平明显诱发谵妄的病例报告，该患者为一名95岁且无前精神疾病史的患者，同时还探讨了其代谢产物去甲喹硫平的潜在作用。
