Lee Hoyoon, Na Wonwhi, Lee Sang Bae, Ahn Chul Woo, Moon Jun Sung, Won Kyu Chang, Shin Sehyun
School of Mechanical Engineering, Korea University, Seoul, South Korea.
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Front Physiol. 2019 Aug 20;10:1062. doi: 10.3389/fphys.2019.01062. eCollection 2019.
Many studies have demonstrated that an alteration in hemorheological properties is closely correlated with diabetic microcirculatory diseases. However, most of these studies have been limited to animal studies or used a small number of clinical samples, due to a lack of effective point-of-care (POC) devices to measure such properties within clinical environments. Owing to recent developments in microfluidic technology, several hemorheological POC devices have been designed that allow for the possibility of conducting extensive clinical studies using hemorheological measurements. Here, we reviewed recent clinical studies of diabetic kidney disease (DKD) associated with hemorheological parameters. We found that RBC deformability alone did not show a significant difference according to the degree of DKD, whereas critical shear stress (CSS) was found to be closely related to the ratio of albumin to creatinine and glomerular filtration rate. We also reviewed studies that alteration of hemorheological properties are associated with the development of DKD, which showed that CSS could be considered as a potential index to diagnose other diabetic complications as well as DKD.
许多研究表明，血液流变学特性的改变与糖尿病微血管疾病密切相关。然而，由于缺乏在临床环境中测量这些特性的有效即时检测（POC）设备，这些研究大多局限于动物研究或使用少量临床样本。由于微流控技术的最新发展，已经设计了几种血液流变学POC设备，这使得使用血液流变学测量进行广泛临床研究成为可能。在此，我们综述了近期与血液流变学参数相关的糖尿病肾病（DKD）临床研究。我们发现，仅红细胞变形性根据DKD程度未显示出显著差异，而临界剪切应力（CSS）与白蛋白与肌酐的比值和肾小球滤过率密切相关。我们还综述了血液流变学特性改变与DKD发生相关的研究，结果表明CSS可被视为诊断其他糖尿病并发症以及DKD的潜在指标。
