Luo Huichun, Huang Yongzhi, Xiao Xiao, Dai Wenjing, Nie Yingnan, Geng Xinyi, Green Alexander L, Aziz Tipu Z, Wang Shouyan
School of Biomedical Engineering, University of Science and Technology of China, Hefei, China.
Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.
Eur J Neurosci. 2020 Jan;51(2):628-640. doi: 10.1111/ejn.14569. Epub 2019 Sep 23.
Understanding the functional dynamics of neural oscillations in the sensory thalamus is essential for elucidating the perception and modulation of neuropathic pain. Local field potentials were recorded from the sensory thalamus of twelve neuropathic pain patients. Single and combinational neural states were defined by the activity state of a single or paired oscillations. Relationships between the duration or occurrence rate of neural state and pre-operative pain level or pain relief induced by deep brain stimulation were evaluated. Results showed that the occurrence rate of the single neural state of low-beta oscillation was significantly correlated with pain relief. The duration and occurrence rate of combinational neural states of the paired low-beta with delta, theta, alpha, high-beta or low-gamma oscillations were more significantly correlated with pain relief than the single neural states. Moreover, these significant combinational neural states formed a local oscillatory network with low-beta oscillation as a key node. The results also showed correlations between measures of combinational neural states and subjective pain level as well. The duration of combinational neural states of paired alpha with delta or theta oscillations and the occurrence rate of neural states of the paired delta with low-beta or low-gamma oscillations were significantly correlated with pre-operative pain level. In conclusion, this study revealed that the integration of oscillations and the functional dynamics of neural states were differentially involved in modulation and perception of neuropathic pain. The functional dynamics could be biomarkers for developing neural state-dependent deep brain stimulation for neuropathic pain.
了解感觉丘脑神经振荡的功能动态对于阐明神经性疼痛的感知和调节至关重要。记录了12名神经性疼痛患者感觉丘脑的局部场电位。通过单个或成对振荡的活动状态定义单个和组合神经状态。评估了神经状态的持续时间或发生率与术前疼痛水平或深部脑刺激引起的疼痛缓解之间的关系。结果表明，低β振荡的单个神经状态的发生率与疼痛缓解显著相关。与单个神经状态相比，低β与δ、θ、α、高β或低γ振荡的成对组合神经状态的持续时间和发生率与疼痛缓解的相关性更强。此外，这些显著的组合神经状态形成了一个以低β振荡为关键节点的局部振荡网络。结果还显示了组合神经状态指标与主观疼痛水平之间的相关性。α与δ或θ振荡的成对组合神经状态的持续时间以及δ与低β或低γ振荡的成对神经状态的发生率与术前疼痛水平显著相关。总之，本研究表明振荡的整合和神经状态的功能动态在神经性疼痛的调节和感知中存在差异参与。功能动态可能是开发用于神经性疼痛的神经状态依赖性深部脑刺激的生物标志物。
