Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain.
Nutrients. 2019 Sep 3;11(9):2069. doi: 10.3390/nu11092069.
Bariatric surgery remains the most effective option for achieving important and sustained weight loss. We explored the effects of Roux-en-Y gastric bypass (RYGB) on the circulating levels of adiponectin, leptin, and the adiponectin/leptin (Adpn/Lep) ratio in patients with obesity and type 2 diabetes (T2D). Twenty-five T2D volunteers undergoing RYGB were included in the study, and further subclassified as patients that responded or not to RYBG, regarding remission of T2D. Anthropometric and biochemical variables were evaluated before and after RYGB. Obese patients with T2D exhibited an increase ( < 0.0001) in the Adpn/Lep ratio after RYGB. Changes in the Adpn/Lep ratio correlated better with changes in anthropometric data ( < 0.001) than with the variations of adiponectin or leptin alone. Multiple regression analysis revealed that the change in the Adpn/Lep ratio in patients with T2D was an independent predictor of the changes in body mass index ( < 0.001) and body fat percentage ( = 0.022). However, the Adpn/Lep ratio did not differ between individuals with or without T2D remission after RYGB. In summary, the current study demonstrated that after weight and body fat loss following RYGB, the Adpn/Lep ratio increased in patients with obesity and T2D.
减重手术仍然是实现重要和持续体重减轻的最有效选择。我们探讨了 Roux-en-Y 胃旁路术（RYGB）对肥胖和 2 型糖尿病（T2D）患者循环中脂联素、瘦素和脂联素/瘦素（Adpn/Lep）比值的影响。25 名接受 RYGB 的 T2D 志愿者被纳入研究，并根据 T2D 的缓解情况进一步分为对 RYBG 有反应和无反应的患者亚组。在 RYGB 前后评估了人体测量学和生化变量。患有 T2D 的肥胖患者在 RYGB 后 Adpn/Lep 比值增加（<0.0001）。Adpn/Lep 比值的变化与人体测量学数据的变化相关性更好（<0.001），而与单独的脂联素或瘦素的变化相关性更好。多元回归分析显示，T2D 患者 Adpn/Lep 比值的变化是体重指数（<0.001）和体脂肪百分比变化的独立预测因子（=0.022）。然而，RYGB 后 T2D 缓解或未缓解的个体之间 Adpn/Lep 比值没有差异。总之，本研究表明，在 RYGB 后体重和体脂肪减轻后，肥胖和 T2D 患者的 Adpn/Lep 比值增加。
