Bottazzo G F, Foulis A K, Bosi E, Todd I, Pujol-Borrell R
Department of Immunology, University College and Middlesex School of Medicine, London, England.
Diabetes Care. 1988 Nov-Dec;11 Suppl 1:24-8.
A model for the possible pathogenesis of insulin-dependent diabetes mellitus (IDDM) is presented. It is partly based on studies of autoimmune thyroiditis and founded on the idea that inappropriate class II molecule expression in insulin-producing beta-cells of pancreatic islets could cause an organ-specific autoimmune disorder. The model is supported by results of several IDDM case studies as well as by the critical evaluation of the known effects of various lymphokines and lymphotoxins on endocrine target tissues. The possible roles of islet capillary endothelial cells and islet cell antibodies in the pathogenesis of IDDM are discussed.
本文提出了一种胰岛素依赖型糖尿病（IDDM）可能的发病机制模型。该模型部分基于自身免疫性甲状腺炎的研究，并基于胰岛中产生胰岛素的β细胞中不适当的II类分子表达可能导致器官特异性自身免疫性疾病这一观点。该模型得到了多个IDDM病例研究结果以及对各种淋巴因子和淋巴毒素对内分泌靶组织已知作用的批判性评估的支持。文中还讨论了胰岛毛细血管内皮细胞和胰岛细胞抗体在IDDM发病机制中的可能作用。
