Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Department of Neurology, Warren Alpert School of Medicine at Brown University, Providence, Rhode Island, USA.
J Neurointerv Surg. 2020 Mar;12(3):233-239. doi: 10.1136/neurintsurg-2019-015033. Epub 2019 Sep 4.
Endovascular therapy (EVT) for stroke improves outcomes but is time sensitive.
To compare times to treatment and outcomes between patients taken to the closest primary stroke center (PSC) with those triaged in the field to a more distant comprehensive stroke center (CSC).
During the study, a portion of our region allowed field triage of patients who met severity criteria to a more distant CSC than the closest PSC. The remaining patients were transported to the closest PSC. We compared times to treatment and clinical outcomes between those two groups. Additionally, we performed a matched-pairs analysis of patients from both groups on stroke severity and distance to CSC.
Over 2 years, 232 patients met inclusion criteria and were closest from the field to a PSC; 144 were taken to the closest PSC and 88 to the more distant CSC. The median additional transport time to the CSC was 7 min. Times from scene departure to alteplase and arterial puncture were faster in the direct group (50 vs 62 min; 93 vs 152 min; p<0.001 for both). Among patients who were independent before the stroke, the OR for less disability in the direct group was 1.47 (95% CI 1.13 to 1.93, p=0.003), and 2.06 (95% CI 1.10 to 3.89, p=0.01) for the matched pairs.
In a densely populated setting, for patients with stroke who are EVT candidates and closest to a PSC from the field, triage to a slightly more distant CSC is associated with faster time to EVT, no delay to alteplase, and less disability at 90 days.
血管内治疗(EVT)可改善中风患者的预后,但治疗时间非常关键。
比较直接转运至最近的初级卒中中心(PSC)与在现场分诊至较远的综合卒中中心(CSC)的患者的治疗时间和结局。
在研究期间,我们所在区域的一部分允许对符合严重程度标准的患者进行现场分诊至较远的 CSC,而不是最近的 PSC。其余患者被转运至最近的 PSC。我们比较了两组患者的治疗时间和临床结局。此外,我们对两组患者的卒中严重程度和与 CSC 的距离进行了匹配对分析。
在 2 年期间,232 名患者符合纳入标准,且距离最近的 PSC 最近;其中 144 名患者被转运至最近的 PSC,88 名患者被转运至较远的 CSC。转运至 CSC 的额外中位运输时间为 7 分钟。直接转运组从现场出发到接受阿替普酶和动脉穿刺的时间更短(50 分钟比 62 分钟;93 分钟比 152 分钟;均<0.001)。在卒中前独立的患者中,直接转运组残疾程度较轻的比值比为 1.47(95%CI 1.13 至 1.93,p=0.003),匹配对为 2.06(95%CI 1.10 至 3.89,p=0.01)。
在人口密集的地区,对于那些符合 EVT 条件且距离 PSC 最近的卒中患者,分诊至稍远的 CSC 与更快的 EVT 时间、阿替普酶无延迟以及 90 天残疾程度较低相关。