茶碱可拮抗地西泮对心室自律性的作用。

Theophylline antagonizes the effect of diazepam on ventricular automaticity.

作者信息

Ruiz F, Hernández J, Ribeiro J A

机构信息

Department of Pharmacology, University of Murcia Medical School, Spain.

出版信息

Eur J Pharmacol. 1988 Oct 18;155(3):205-9. doi: 10.1016/0014-2999(88)90505-5.

DOI:10.1016/0014-2999(88)90505-5

PMID:3148474

Abstract

The effect of diazepam on ventricular automaticity induced by a local injury was investigated in the isolated right ventricle of the rat in the presence of the diazepam central antagonist, RO 15-1788, and of the adenosine antagonist, theophylline. Theophylline but not RO 15-1788 antagonized the inhibitory effect induced by diazepam on ventricular automaticity. The inhibitory effect of adenosine but not that of 2-chloroadenosine was potentiated in the presence of diazepam. The results suggest that the inhibitory effect of diazepam on ventricular automaticity results from the inhibition of adenosine uptake.

摘要

在存在地西泮中枢拮抗剂RO 15 - 1788和腺苷拮抗剂茶碱的情况下，研究了地西泮对大鼠离体右心室局部损伤诱导的心室自律性的影响。茶碱而非RO 15 - 1788拮抗了地西泮对心室自律性的抑制作用。在地西泮存在的情况下，腺苷而非2 - 氯腺苷的抑制作用增强。结果表明，地西泮对心室自律性的抑制作用源于对腺苷摄取的抑制。