Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China.
Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China.
Biosci Rep. 2019 Sep 20;39(9). doi: 10.1042/BSR20190488. Print 2019 Sep 30.
Mangiferin (2-β-d-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one), a xanthanoid, is one of the major compounds isolated from mango leaves and bark fruit. Previous studies have identified several properties of mangiferin, such as preventing microbial growth, reducing oxidative stress and helping reduce risk of diabetes. The aim of the present study is to explore the potential anti-dementia effects of Mangiferin in a senescence-accelerated mouse prone 8 (SAMP8) mouse model. Morris water maze (MWM) test showed that mangiferin significantly improved the learning and memory retention in SAMP8 mice. In addition, mangiferin reduced the damage in hippocampal neurons and mitochondria, and decreased the expression of amyloid-β (Aβ1-40 and Aβ1-42); however, no influence on the expression of amyloid precursor protein (APP) within the brain of SAMP8 mice. Moreover, Mangiferin inhibited lipid peroxidation (LPO). In conclusion, we provided evidences to show that mangiferin significantly restored the learning and memory impairment in the SAMP8 mouse model, and reduced the pathological injury in hippocampal by modulating lipid oxidation and amyloid-β deposition in the brain.
芒果苷（2-β-D-吡喃葡萄糖基-1,3,6,7-四羟基-9H-呫吨-9-酮），一种呫吨酮类化合物，是从芒果叶和果皮中分离得到的主要化合物之一。先前的研究已经确定了芒果苷的几种特性，如防止微生物生长、减轻氧化应激和帮助降低糖尿病风险。本研究旨在探索芒果苷在快速老化模型 8 号小鼠（SAMP8）模型中的潜在抗痴呆作用。Morris 水迷宫（MWM）测试表明，芒果苷可显著改善 SAMP8 小鼠的学习和记忆保留能力。此外，芒果苷减少了海马神经元和线粒体的损伤，并降低了淀粉样蛋白-β（Aβ1-40 和 Aβ1-42）的表达；然而，对 SAMP8 小鼠大脑中的淀粉样前体蛋白（APP）表达没有影响。此外，芒果苷抑制脂质过氧化（LPO）。总之，我们提供的证据表明，芒果苷可显著恢复 SAMP8 小鼠模型的学习和记忆障碍，并通过调节大脑中的脂质氧化和淀粉样蛋白-β沉积来减轻海马的病理损伤。
