Murphy G M, Greaves M W, Zollman P E, Winkelmann R K
St John's Hospital for Diseases of the Skin, London, UK.
Dermatologica. 1988;177(6):338-40. doi: 10.1159/000248603.
Passive transfer experiments in cholinergic urticaria were carried out from 16 patients to a Macaca cymnologous monkey. Intravenous Evans blue dye was used to demonstrate vascular permeability. The animal was challenged after 24 h first by heating the serum-injected dorsal skin to 45 degrees C and secondly by superinjection of acetylcholine into serum-injected sites, and a control site. Local heat proved insufficient to evoke a response. Seven of 16 serum-injected sites showed positive reaction to acetylcholine, control injection of acetylcholine did not. These experiments suggest the presence of a serum factor in cholinergic urticaria which, with acetylcholine, causes increased vascular permeability.
在胆碱能性荨麻疹患者中进行了被动转移实验，将16名患者的血清转移至一只食蟹猴体内。使用静脉注射伊文思蓝染料来证明血管通透性。24小时后，首先通过将注射血清的背部皮肤加热至45摄氏度，其次通过向注射血清的部位和一个对照部位超注射乙酰胆碱来对动物进行激发，结果发现局部加热不足以引发反应。16个注射血清的部位中有7个对乙酰胆碱呈阳性反应，而乙酰胆碱对照注射则未出现此反应。这些实验表明胆碱能性荨麻疹中存在一种血清因子，该因子与乙酰胆碱一起会导致血管通透性增加。
