Glushkov Andrew N, Polenok Elena G
Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, Kemerovo 650065, Russian Federation.
Saudi J Biol Sci. 2019 Feb;26(2):244-251. doi: 10.1016/j.sjbs.2017.09.014. Epub 2017 Oct 3.
The experimental and clinical data about antibodies against environmental chemical carcinogens and endogenous steroids are represented. The conception of immunomodulation of carcinogens- and steroids-dependent human diseases is proposed. It is postulated that antibodies to polycyclic aromatic hydrocarbons and heterocyclic amines in cooperation with antibodies to cholesterol, sex hormones, mineralo- and glucocorticoids stimulate or inhibit cancer, malformation, cardiovascular and autoimmune diseases depending on their personal combination. It is recommended to use immunoassay of these antibodies for the human diseases prediction. The alternative approaches for prevention using the probiotics transformed by anti-carcinogen antibodies are substantiated.
文中展示了关于抗环境化学致癌物和内源性类固醇抗体的实验及临床数据。提出了对致癌物和类固醇依赖性人类疾病进行免疫调节的概念。据推测，多环芳烃和杂环胺的抗体与胆固醇、性激素、矿物质和糖皮质激素的抗体协同作用，根据它们的个体组合刺激或抑制癌症、畸形、心血管疾病和自身免疫性疾病。建议使用这些抗体的免疫测定法来预测人类疾病。证实了使用经抗癌原抗体转化的益生菌进行预防的替代方法。
