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大承气汤通过抑制JAK2-STAT3信号通路减轻重症急性胰腺炎大鼠的肠道损伤。

Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway.

作者信息

Jin Wenyin, Shen Yinfeng

机构信息

Department of Surgery, Hubei Hospital of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, China.

出版信息

Evid Based Complement Alternat Med. 2019 Aug 14;2019:3909468. doi: 10.1155/2019/3909468. eCollection 2019.

DOI:10.1155/2019/3909468
PMID:31485245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6710798/
Abstract

OBJECTIVE

To investigate the effect of Da-Cheng-Qi decoction (DCQD) on treating intestinal injury in rats with severe acute pancreatitis (SAP), based on the Janus kinase 2 (JAK2)/signal transducers and transcription 3 (STAT3) signaling pathway.

METHODS

Rats were randomly divided into the SAP group, SAP + ruxolitinib (JAK2 inhibitor) group, SAP + Stattic (STAT3 inhibitor) group, SAP + DCQD group, and sham operation group. They were further divided into 3-hour, 6-hour, 12-hour, and 18-hour subgroups. Levels of amylase and the inflammatory cytokines tumor necrosis factor-, interleukin 6, interleukin 10, and interleukin 4 in plasma were tested. The messenger ribonucleic acid (mRNA) expression of JAK2 and STAT3 and the protein expression of phosphorylated JAK2 (p-JAK2) and phosphorylated STAT3 (p-STAT3) in the pancreas and terminal ileum tissues were examined.

RESULTS

Rats with SAP had severe changes in plasma levels of amylase and inflammatory cytokines and showed an overexpression of JAK2 mRNA, STAT3 mRNA, p-JAK2 protein, and p-STAT3 protein in the pancreas and terminal ileum. The events could be downregulated by treatment with DCQD, JAK2 inhibitor, and STAT3 inhibitor.

CONCLUSIONS

In rats with SAP, DCQD ameliorated inflammatory cytokines and intestinal injury, which may be closely associated with the inhibition of the JAK2/STAT3 signaling pathway.

摘要

目的

基于Janus激酶2（JAK2）/信号转导子与转录激活子3（STAT3）信号通路，探讨大承气汤（DCQD）对重症急性胰腺炎（SAP）大鼠肠损伤的治疗作用。

方法

将大鼠随机分为SAP组、SAP + 鲁索替尼（JAK2抑制剂）组、SAP + Stattic（STAT3抑制剂）组、SAP + DCQD组和假手术组。再将每组进一步分为3小时、6小时、12小时和18小时亚组。检测血浆中淀粉酶水平以及炎症细胞因子肿瘤坏死因子-α、白细胞介素6、白细胞介素10和白细胞介素4水平。检测胰腺和回肠末端组织中JAK2和STAT3的信使核糖核酸（mRNA）表达以及磷酸化JAK2（p-JAK2）和磷酸化STAT3（p-STAT3）的蛋白表达。

结果

SAP大鼠血浆中淀粉酶水平和炎症细胞因子有严重变化，胰腺和回肠末端JAK2 mRNA、STAT3 mRNA、p-JAK2蛋白和p-STAT3蛋白呈过表达。给予DCQD、JAK2抑制剂和STAT3抑制剂治疗可下调上述指标。

结论

在SAP大鼠中，DCQD可改善炎症细胞因子和肠损伤，这可能与抑制JAK2/STAT3信号通路密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf46/6710798/e9d29228cce3/ECAM2019-3909468.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf46/6710798/e9d29228cce3/ECAM2019-3909468.008.jpg

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