成人T细胞白血病细胞中甲状旁腺激素相关蛋白的产生。
Production of parathyroid hormone-related protein in adult T-cell leukemia cells.
作者信息
Honda S, Yamaguchi K, Miyake Y, Hayashi N, Adachi N, Kinoshita K, Ikehara O, Kimura S, Kinoshita T, Shimotohno K
机构信息
Growth Factor Division, National Cancer Center Research Institute, Tokyo.
出版信息
Jpn J Cancer Res. 1988 Dec;79(12):1264-8. doi: 10.1111/j.1349-7006.1988.tb01554.x.
Abstract
Human parathyroid hormone-related protein (PTHrP) mRNA was detected in peripheral leukemic cells obtained from adult T-cell leukemia (ATL) patients as well as in cultured human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines. In contrast, PTHrP mRNA was not detected in other types of leukemic cells. Using radioimmunoassay, immunoreactive PTHrP was also detected in the spent media of HTLV-I-infected T-cell lines. These results suggest that PTHrP plays an important role in developing the hypercalcemia frequently observed in ATL patients.
摘要
在从成人T细胞白血病（ATL）患者获取的外周白血病细胞以及培养的人I型T细胞白血病病毒（HTLV-I）感染的T细胞系中检测到了人甲状旁腺激素相关蛋白（PTHrP）mRNA。相比之下，在其他类型的白血病细胞中未检测到PTHrP mRNA。使用放射免疫测定法，在HTLV-I感染的T细胞系的培养液中也检测到了免疫反应性PTHrP。这些结果表明，PTHrP在ATL患者中常见的高钙血症的发生中起重要作用。
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