和 基因多态性与哮喘儿童吸入皮质激素反应相关。
Gene polymorphisms in and are associated with response to inhaled corticosteroids in children with asthma.
机构信息
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, PR China.
Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, PR China.
出版信息
Pharmacogenomics. 2019 Aug;20(13):947-955. doi: 10.2217/pgs-2019-0036.
The purpose of this study was to investigate the involvement of single-nucleotide polymorphisms in , and in the response to inhaled corticosteroids in asthmatic children. Children with mild-to-moderate asthma were enrolled in the study. The SEQUENOM MassARRAY method was used to sequence 27 SNP genotypes. By ranking the data from smallest to largest, we could infer whether the change in distribution of forced expiratory volume in one second/forced vital capcacity (FEV/FVC) and fractional exhaled nitric oxide differed between genotype groups. rs3025039 T allele carriers had a smaller change in FEV than CC carriers (p = 0.040), and in rs3809324, the frequency of T allele carriers was lower than that of GG carriers (p = 0.048). rs3025039 was also associated with changes in FEV/FVC (p = 0.016). and polymorphisms are significantly associated with the response to inhaled corticosteroids in asthmatic children.
本研究旨在探讨单核苷酸多态性在儿童哮喘患者对吸入性皮质类固醇反应中的作用。纳入了轻度至中度哮喘儿童进行研究。采用 SEQUENOM MassARRAY 方法对 27 个 SNP 基因型进行测序。通过从小到大对数据进行排序，可以推断出在一秒用力呼气量/用力肺活量（FEV/FVC）和呼气中一氧化氮分数（FeNO）的分布变化方面，基因型组之间是否存在差异。rs3025039 T 等位基因携带者的 FEV 变化小于 CC 携带者（p=0.040），而在 rs3809324 中，T 等位基因携带者的频率低于 GG 携带者（p=0.048）。rs3025039 也与 FEV/FVC 的变化相关（p=0.016）。rs3025039 和 rs3809324 多态性与儿童哮喘患者对吸入性皮质类固醇的反应显著相关。
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