量子点：下一代智能纳米系统
Quantum Dots: Next Generation of Smart Nano-Systems.
作者信息
Jahangir Mohammed Asadullah, Gilani Sadaf Jamal, Muheem Abdul, Jafar Mohammed, Aslam Mohammed, Ansari Mohammed Tahir, Barkat Mohammed Abul
机构信息
Department of Pharmaceutics, Nibha Institute of Pharmaceutical Sciences, Karimpur, Rajgir, Nalanda- 803116, Bihar, India.
Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 2014, Aljouf, Saudi Arabia.
出版信息
Pharm Nanotechnol. 2019;7(3):234-245. doi: 10.2174/2211738507666190429113906.
BACKGROUND
The amalgamation of biological sciences with nano stuff has significantly expedited the progress of biological strategies, greatly promoting practical applications in biomedical fields.
OBJECTIVE
With distinct optical attributes (e.g., robust photostability, restricted emission spectra, tunable broad excitation, and high quantum output), fluorescent quantum dots (QDs) have been feasibly functionalized with manageable interfaces and considerably utilized as a new class of optical probe in biological investigations.
METHODS
In this review article, we structured the current advancements in the preparation methods and attributes of QDs. Furthermore, we extend an overview of the outstanding potential of QDs for biomedical research and radical approaches to drug delivery.
CONCLUSION
Notably, the applications of QDs as smart next-generation nanosystems for neuroscience and pharmacokinetic studies have been explained. Moreover, recent interests in the potential toxicity of QDs are also apprised, ranging from cell investigations to animal studies.
背景
生物科学与纳米材料的融合显著加速了生物策略的发展，极大地推动了在生物医学领域的实际应用。
目的
由于具有独特的光学特性（如强大的光稳定性、受限的发射光谱、可调谐的宽激发范围和高量子产率），荧光量子点（QDs）已通过可管理的界面进行了可行的功能化，并在生物研究中被大量用作一类新型光学探针。
方法
在这篇综述文章中，我们梳理了量子点制备方法和特性方面的当前进展。此外，我们还概述了量子点在生物医学研究中的巨大潜力以及药物递送的激进方法。
结论
值得注意的是，已对量子点作为用于神经科学和药代动力学研究的智能下一代纳米系统的应用进行了解释。此外，还介绍了近期对量子点潜在毒性的关注，范围从细胞研究到动物研究。
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