肺动脉平滑肌中的非常规内皮型一氧化氮合酶：为何会存在于此？ - Suppr

Unconventional eNOS in pulmonary artery smooth muscles: why should it be there?

作者信息

Kang Tong Mook

机构信息

Department of Physiology, Sungkyunkwan University School of Medicine, 2066 Seobu-ro, Jangan-gu, Suwon, 16419, Republic of Korea.

出版信息

Pflugers Arch. 2019 Oct;471(10):1245-1246. doi: 10.1007/s00424-019-02308-w. Epub 2019 Sep 5.

DOI:10.1007/s00424-019-02308-w

PMID:31486900

Abstract

摘要

相似文献

Unconventional eNOS in pulmonary artery smooth muscles: why should it be there?肺动脉平滑肌中的非常规内皮型一氧化氮合酶：为何会存在于此？

Pflugers Arch. 2019 Oct;471(10):1245-1246. doi: 10.1007/s00424-019-02308-w. Epub 2019 Sep 5.

Wall stretch and thromboxane A₂ activate NO synthase (eNOS) in pulmonary arterial smooth muscle cells via H₂O₂ and Akt-dependent phosphorylation.壁拉伸和血栓素A₂通过过氧化氢和Akt依赖性磷酸化激活肺动脉平滑肌细胞中的一氧化氮合酶（eNOS）。

Pflugers Arch. 2016 Apr;468(4):705-16. doi: 10.1007/s00424-015-1778-1. Epub 2016 Jan 4.

Hydrogen sulfide facilities production of nitric oxide via the Akt/endothelial nitric oxide synthases signaling pathway to protect human umbilical vein endothelial cells from injury by angiotensin II.硫化氢设施通过 Akt/内皮型一氧化氮合酶信号通路生产一氧化氮，以保护人脐静脉内皮细胞免受血管紧张素 II 的损伤。

Mol Med Rep. 2017 Nov;16(5):6255-6261. doi: 10.3892/mmr.2017.7328. Epub 2017 Aug 22.

H S-induced gastric fundus smooth muscle tension potentiation is mediated by the phosphoinositide 3-kinase/Akt/endothelial nitric oxide synthase pathway.硫化氢诱导的胃底平滑肌张力增强是由磷酸肌醇3激酶/蛋白激酶B/内皮型一氧化氮合酶途径介导的。

Exp Physiol. 2017 Jul 1;102(7):779-790. doi: 10.1113/EP086288. Epub 2017 Jun 1.

Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor.血管紧张素II通过2型受体刺激腹主动脉结扎小鼠胸主动脉中的内皮型一氧化氮合酶磷酸化。

Hypertension. 2006 Nov;48(5):958-64. doi: 10.1161/01.HYP.0000244108.30909.27. Epub 2006 Sep 25.

PI3K/AKT signaling pathway plays a role in enhancement of eNOS activity by recombinant human angiotensin converting enzyme 2 in human umbilical vein endothelial cells.PI3K/AKT信号通路在重组人血管紧张素转换酶2增强人脐静脉内皮细胞中内皮型一氧化氮合酶活性的过程中发挥作用。

Int J Clin Exp Pathol. 2014 Oct 15;7(11):8112-7. eCollection 2014.

Cellular mechanisms and intracellular signaling pathways for the modulation of eNOS in pulmonary arteries by 15-HETE.15-羟基二十碳四烯酸对肺动脉中内皮型一氧化氮合酶调节的细胞机制及细胞内信号通路

J Recept Signal Transduct Res. 2012 Apr;32(2):87-95. doi: 10.3109/10799893.2012.660530. Epub 2012 Mar 6.

Angiotensin II causes endothelial dysfunction via the GRK2/Akt/eNOS pathway in aortas from a murine type 2 diabetic model.血管紧张素 II 通过 GRK2/Akt/eNOS 通路引起 2 型糖尿病小鼠主动脉内皮功能障碍。

Pharmacol Res. 2011 Nov;64(5):535-46. doi: 10.1016/j.phrs.2011.05.001. Epub 2011 May 6.

Tert-butylhydroquinone lowers blood pressure in AngII-induced hypertension in mice via proteasome-PTEN-Akt-eNOS pathway.叔丁基对苯二酚通过蛋白酶体-PTEN-Akt-eNOS 通路降低 AngII 诱导的高血压小鼠的血压。

Sci Rep. 2016 Jul 20;6:29589. doi: 10.1038/srep29589.

Losartan, an angiotensin II type 1 receptor blocker, ameliorates cerebral ischemia-reperfusion injury via PI3K/Akt-mediated eNOS phosphorylation.氯沙坦，一种血管紧张素 II 型 1 型受体阻滞剂，通过 PI3K/Akt 介导的 eNOS 磷酸化改善脑缺血再灌注损伤。

Brain Res Bull. 2012 Oct 1;89(1-2):65-70. doi: 10.1016/j.brainresbull.2012.06.010. Epub 2012 Jul 2.

引用本文的文献

Mechanism of Hypoxia-Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling.缺氧介导的平滑肌细胞增殖导致血管重构的机制。

Biomed Res Int. 2022 Dec 24;2022:3959845. doi: 10.1155/2022/3959845. eCollection 2022.

Endothelial regulation of calmodulin expression and eNOS-calmodulin interaction in vascular smooth muscle.血管平滑肌中钙调蛋白表达和 eNOS-钙调蛋白相互作用的内皮调节。

Mol Cell Biochem. 2022 May;477(5):1489-1498. doi: 10.1007/s11010-022-04391-7. Epub 2022 Feb 16.

本文引用的文献

Fast relaxation and desensitization of angiotensin II contraction in the pulmonary artery via AT1R and Akt-mediated phosphorylation of muscular eNOS.通过 AT1R 和 Akt 介导的肌型 eNOS 磷酸化实现肺动脉中血管紧张素 II 收缩的快速弛豫和脱敏。

Pflugers Arch. 2019 Oct;471(10):1317-1330. doi: 10.1007/s00424-019-02305-z. Epub 2019 Aug 30.

New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease.内皮型一氧化氮合酶（eNOS）功能/障碍在心血管疾病中的新治疗意义。

Int J Mol Sci. 2019 Jan 7;20(1):187. doi: 10.3390/ijms20010187.

Histone deacetylase inhibitors promote eNOS expression in vascular smooth muscle cells and suppress hypoxia-induced cell growth.组蛋白去乙酰化酶抑制剂可促进血管平滑肌细胞中内皮型一氧化氮合酶的表达，并抑制缺氧诱导的细胞生长。

J Cell Mol Med. 2017 Sep;21(9):2022-2035. doi: 10.1111/jcmm.13122. Epub 2017 Mar 7.

Synthesis and Biological Evaluation of New N-(4-Substituted phenyl)glycine Derivatives as Potential Anti-inflammatory Agents.

Antiinflamm Antiallergy Agents Med Chem. 2016;15(2):127-134. doi: 10.2174/1871523015666160518120501.

Pflugers Arch. 2016 Apr;468(4):705-16. doi: 10.1007/s00424-015-1778-1. Epub 2016 Jan 4.

Compartmentalized nitric oxide signaling in the resistance vasculature.阻力血管中一氧化氮信号的区域化

Nitric Oxide. 2015 Sep 15;49:8-15. doi: 10.1016/j.niox.2015.05.003. Epub 2015 May 28.

Hypoxia-augmented constriction of deep femoral artery mediated by inhibition of eNOS in smooth muscle.缺氧通过抑制平滑肌内皮型一氧化氮合酶增强股深动脉收缩。

Am J Physiol Cell Physiol. 2013 Jan 1;304(1):C78-88. doi: 10.1152/ajpcell.00176.2012. Epub 2012 Oct 24.

Sub-cellular targeting of constitutive NOS in health and disease.在健康和疾病中组成型 NOS 的亚细胞靶向作用。

J Mol Cell Cardiol. 2012 Feb;52(2):341-50. doi: 10.1016/j.yjmcc.2011.09.006. Epub 2011 Sep 16.

The role of arterial smooth muscle in vasorelaxation.动脉平滑肌在血管舒张中的作用。

Biochem Biophys Res Commun. 2008 Dec 12;377(2):504-507. doi: 10.1016/j.bbrc.2008.10.019. Epub 2008 Oct 16.

An in situ evidence for autocrine function of NO in the vasculature.血管中一氧化氮自分泌功能的原位证据。

Nitric Oxide. 2004 Jun;10(4):203-12. doi: 10.1016/j.niox.2004.04.004.

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Unconventional eNOS in pulmonary artery smooth muscles: why should it be there?

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