Albert Chonyang L
Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Desk J3-4, Cleveland, OH, 44195, USA.
Heart and Vascular Institute, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, OH, USA.
Curr Treat Options Cardiovasc Med. 2019 Sep 5;21(10):52. doi: 10.1007/s11936-019-0754-z.
This review will define morbid obesity and relationship between morbid obesity and heart failure syndromes. It will delve into unique challenges facing patients with dual diagnoses of heart failure and morbid obesity and examine the data that obesity should be a target in the treatment of heart failure.
Emerging literature has indicated the safety and efficacy of surgical weight loss in patients with heart failure. Furthermore, bariatric surgery with associated weight loss has been associated with improvements in heart failure symptoms and reverse remodeling on echocardiography. In patients with advanced heart failure, bariatric surgery has led to improvement in heart failure to obviate the need for cardiac transplantation or sufficient weight loss for cardiac transplant eligibility. In heart failure patients who are morbidly obese, treatment of obesity is an effective therapeutic target with a myriad of potential benefits.
本综述将定义病态肥胖以及病态肥胖与心力衰竭综合征之间的关系。它将深入探讨心力衰竭和病态肥胖双重诊断患者所面临的独特挑战，并审视肥胖应成为心力衰竭治疗靶点的数据。
新出现的文献表明，手术减肥对心力衰竭患者具有安全性和有效性。此外，减肥手术及相关体重减轻与心力衰竭症状改善及超声心动图显示的逆向重构有关。在晚期心力衰竭患者中，减肥手术已使心力衰竭得到改善，从而无需进行心脏移植或实现足够的体重减轻以符合心脏移植条件。对于病态肥胖的心力衰竭患者，治疗肥胖是一个具有诸多潜在益处的有效治疗靶点。
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