State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, 999078, Macau SAR, China.
Department of Chemistry, Hong Kong Baptist University, Kowloon, 999077, Hong Kong SAR, China.
J Biol Inorg Chem. 2019 Dec;24(8):1159-1170. doi: 10.1007/s00775-019-01712-y. Epub 2019 Sep 5.
Alzheimer's disease (AD) is a type of neurodegenerative malady that is associated with the accumulation of amyloid plaques. Metal ions are critical for the development and upkeep of brain activity, but metal dyshomeostasis can contribute to the development of neurodegenerative diseases, including AD. This review highlights the association between metal dyshomeostasis and AD pathology, the feasibility of rebalancing metal homeostasis as a therapeutic strategy for AD, and a survey of current drugs that action via rebalancing metal homeostasis. Finally, we discuss the challenges that should be overcome by researchers in the future to enable the practical use of metal homeostasis rebalancing agents for clinical application.
阿尔茨海默病（AD）是一种神经退行性疾病，与淀粉样斑块的积累有关。金属离子对大脑活动的发展和维持至关重要，但金属离子动态平衡失调可导致神经退行性疾病的发展，包括 AD。本综述强调了金属离子动态平衡失调与 AD 病理之间的关系，重新平衡金属离子动态平衡作为 AD 治疗策略的可行性，以及对通过重新平衡金属离子动态平衡起作用的现有药物的调查。最后，我们讨论了研究人员未来应该克服的挑战，以使金属离子动态平衡再平衡剂能够实际用于临床应用。
