O'Quinn Michael P, Mazzella Anthony J, Kumar Prabhat
Division of Cardiology, University of North Carolina Hospitals, UNC Center for Heart & Vascular Care, 6th Floor, Burnett-Womack Building, 160 Dental Circle CB #7075, Chapel Hill, NC, 27599-7075, USA.
Curr Treat Options Cardiovasc Med. 2019 Sep 5;21(10):53. doi: 10.1007/s11936-019-0755-y.
Premature ventricular contractions (PVCs) are arrhythmias with presentation ranging from asymptomatic and benign to symptomatic, frequent and capable of inducing cardiomyopathy. Work in the late 1970s-1980s showed that they could be representative of underlying coronary artery disease, hypertension, or left ventricular hypertrophy. Furthermore, their presence is independently linked to an increased risk of stroke and sudden cardiac death. Since characterization of PVC-induced cardiomyopathy 21 years ago, there has been progressive interest in treating PVCs. This review aims to present an approach that practitioners can use for the treatment of PVCs.
Recent efforts have focused on optimizing techniques for mapping and ablation of PVCs in patients with symptoms or reduced LVEF. However, an understanding of the medical treatment options is necessary because medical management is still the first line of therapy. The practitioner will need to weigh the risks and benefits of these strategies in order to help the patient determine the best course of action. PVCs are recognized as a clinically significant arrhythmia, and evolving treatment strategies can improve cardiovascular outcomes. This review provides a concise summary of the current state of PVC treatment.
室性早搏（PVCs）是一种心律失常，其表现范围从无症状和良性到有症状、频发且能够诱发心肌病。20世纪70年代末至80年代的研究表明，它们可能是潜在冠状动脉疾病、高血压或左心室肥厚的表现。此外，它们的存在与中风和心源性猝死风险增加独立相关。自21年前确定PVC诱发的心肌病以来，对治疗PVCs的兴趣不断增加。本综述旨在介绍一种医生可用于治疗PVCs的方法。
最近的努力集中在优化对有症状或左心室射血分数降低患者的PVCs进行标测和消融的技术。然而，了解药物治疗选择是必要的，因为药物治疗仍然是一线治疗方法。医生需要权衡这些策略的风险和益处，以帮助患者确定最佳行动方案。PVCs被认为是一种具有临床意义的心律失常，不断发展的治疗策略可以改善心血管结局。本综述简要总结了PVC治疗的现状。
