Taylor W R
National Institute for Medical Research (MRC), London, United Kingdom.
J Mol Evol. 1988;28(1-2):161-9. doi: 10.1007/BF02143508.
A method for the alignment of two or more biological sequences is described. The method is a direct extension of the method of Taylor (1987) incorporating a consensus sequence approach and allows considerable freedom in the control of the clustering of the sequences. At one extreme this is equivalent to the earlier method (Taylor 1987), whereas at the other, the clustering approaches the binary method of Feng and Doolittle (1987). Such freedom allows the program to be adapted to particular problems, which has the important advantage of resulting in considerable savings in computer time, allowing very large problems to be tackled. Besides a detailed analysis of the alignment of the cytochrome c superfamily, the clustering and alignment of the PIR sequence data bank (3500 sequences approx.) is described.
描述了一种用于比对两个或更多生物序列的方法。该方法是泰勒（1987年）方法的直接扩展，纳入了共有序列方法，并在控制序列聚类方面具有相当大的自由度。在一个极端情况下，这等同于早期方法（泰勒，1987年），而在另一个极端情况下，聚类接近冯和杜利特尔（1987年）的二元方法。这种自由度使该程序能够适应特定问题，这具有重要优势，即能大幅节省计算机时间，从而可以处理非常大的问题。除了对细胞色素c超家族比对的详细分析外，还描述了PIR序列数据库（约3500个序列）的聚类和比对。
