一个多序列比对程序。
A multiple sequence alignment program.
作者信息
Sobel E, Martinez H M
出版信息
Nucleic Acids Res. 1986 Jan 10;14(1):363-74. doi: 10.1093/nar/14.1.363.
Abstract
A program is described for simultaneously aligning two or more molecular sequences which is based on first finding common segments above a specified length and then piecing these together to maximize an alignment scoring function. Optimal as well as near-optimal alignments are found, and there is also provided a means for randomizing the given sequences for testing the statistical significance of an alignment. Alignments may be made in the original alphabets of the sequences or in user-specified alternate ones to take advantage of chemical similarities (such as hydrophobic-hydrophilic).
摘要
描述了一种用于同时比对两个或多个分子序列的程序，该程序基于首先找到指定长度以上的共同片段，然后将这些片段拼接在一起以最大化比对评分函数。可以找到最优以及接近最优的比对结果，并且还提供了一种对给定序列进行随机化处理的方法，以测试比对的统计显著性。比对可以在序列的原始字母表中进行，也可以在用户指定的替代字母表中进行，以利用化学相似性（例如疏水-亲水）。
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本文引用的文献
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