Department of Ophthalmology, Kahramanmaras Sutcu Imam University, School of Medicine, Kahramanmaras, Turkey.
Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, School of Medicine, Kahramanmaras, Turkey.
Pregnancy Hypertens. 2019 Jul;17:203-208. doi: 10.1016/j.preghy.2019.07.001. Epub 2019 Jul 4.
The aim of the present study was to examine the effects of preeclampsia on posterior ocular blood flow through optic coherence tomography angiography (OCTA).
The study included preeclamptic pregnant women (group PPW), healthy pregnant women (group HPW) and control non-pregnant women (group CNPW). The blood flow area of retina, optic nerve head and choriocapillaris were assessed through OCTA.
Retinal superficial blood flow area (RSBFA) was similar in group PPW, HPW and CNPW (p = 0.101); likewise, there was not any difference in retinal superficial parafoveal vessel density (RSPFD) between the groups (p = 0.685). There was not any difference detected in retinal deep blood flow area (RDBFA) in group PPW, HPW and CNPW), likewise retinal deep parafoveal vessel density (RDPFD) was found similar between the groups (p = 0.184). The choriocapillaris blood flow area (CBFA) was different between the groups (p = 0.000) and less in the group PPW than in group HPW. The CBFA was 1.875 ± 0.05 mm in group the PPW, 1.928 ± 0.05 mm in the group HPW and 1.464 ± 0.06 mm in the group CNPW. Similarly, the optic nerve head blood flow area was lower in the group PPW compared to the group HPW (1.567 ± 0.38 mm, 1.690 ± 0.20 mm and 1.592 ± 0.25 mm in the group PPW, group HPW and group CNPW respectively; p = 0.002).
Posterior segment ocular blood flow may be diminished in preeclamptic women. OCTA may enable to monitor ocular blood flow dynamics and give important clues in the diagnosis of retinal vascular pathologies accompanied by systemic diseases.
本研究旨在通过光相干断层扫描血管造影术（OCTA）检查子痫前期对后眼部血流的影响。
该研究纳入了子痫前期孕妇（PPW 组）、健康孕妇（HPW 组）和非妊娠对照组（CNPW 组）。通过 OCTA 评估视网膜、视神经头和脉络膜毛细血管的血流面积。
PPW 组、HPW 组和 CNPW 组的视网膜浅层血流面积（RSBFA）相似（p=0.101）；同样，各组间视网膜浅层旁中心血管密度（RSPFD）也无差异（p=0.685）。PPW 组、HPW 组和 CNPW 组的视网膜深层血流面积（RDBFA）无差异，视网膜深层旁中心血管密度（RDPFD）也相似（p=0.184）。各组间脉络膜毛细血管血流面积（CBFA）不同（p=0.000），PPW 组低于 HPW 组。PPW 组的 CBFA 为 1.875±0.05mm，HPW 组为 1.928±0.05mm，CNPW 组为 1.464±0.06mm。同样，与 HPW 组相比，PPW 组视神经头血流面积较低（PPW 组、HPW 组和 CNPW 组分别为 1.567±0.38mm、1.690±0.20mm 和 1.592±0.25mm；p=0.002）。
子痫前期妇女后段眼部血流可能减少。OCTA 可用于监测眼部血流动力学，并为伴有全身疾病的视网膜血管病变的诊断提供重要线索。
