严重先兆子痫患者入院时的血浆乳酸浓度与母体并发症的关系。
Association of plasma lactate concentration at admission of severe preeclampsia to maternal complications.
机构信息
BCNatal. Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia, Obstetricia i Neonatologia Fetal i+D Fetal Medicine Research Center, Barcelona, Catalonia, Spain.
Obstetrical High-Dependency Unit; E.S.E. Hospital San Rafael de Facatativa, Colombia.
出版信息
Pregnancy Hypertens. 2019 Jul;17:89-93. doi: 10.1016/j.preghy.2019.05.003. Epub 2019 May 3.
OBJECTIVE
To evaluate in women with severe preeclampsia the association of lactate concentration at admission with maternal complications.
METHODS
A prospective cohort was created of women with severe preeclampsia consecutively admitted to an Obstetrical High-Dependency Unit. Plasma lactate concentration was measured at admission and its association to maternal complication was evaluated.
RESULTS
A total of 100 women were included, of which 30 (30%) had a maternal complication. The mean lactate plasma concentration in this group was significantly higher than in those uncomplicated cases (2.38 vs 3.1 mmol/L; p < 0.01). A total of 37 (37%) women had lactate concentrations at >3 mmol/L, which was associated to higher incidence of maternal complications (19% vs. 48.6%; p = 0.002; OR 4.03 [95% CI 1.64-9.9]). This association remained independent of other standard severity criteria (OR 3.89; 95%CI 1.22-12.4; p = 0.022).
CONCLUSION
Increased plasma lactate concentrations at admission in women with severe preeclampsia are independently associated to maternal complications.
目的
评估严重子痫前期女性入院时的血乳酸浓度与母体并发症的关系。
方法
创建了一个连续纳入产科高依赖病房严重子痫前期女性的前瞻性队列。入院时测量血浆乳酸浓度，并评估其与母体并发症的关系。
结果
共纳入 100 例女性，其中 30 例（30%）发生了母体并发症。该组的平均血乳酸浓度明显高于无并发症组（2.38 与 3.1mmol/L；p<0.01）。共有 37 例（37%）女性的血乳酸浓度>3mmol/L，与更高的母体并发症发生率相关（19%与 48.6%；p=0.002；OR 4.03 [95%CI 1.64-9.9]）。这种关联独立于其他标准严重程度标准（OR 3.89；95%CI 1.22-12.4；p=0.022）。
结论
严重子痫前期女性入院时的血乳酸浓度升高与母体并发症独立相关。
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