Laboratory of Human Nutrition, Institute of Food Nutrition and Health, ETH Zurich, 8092 Zurich, Switzerland.
Laboratoire de Nutrition, Département de Biologie Animale, Faculté des Sciences et Techniques, Université Cheikh Anta Diop de Dakar, 5005 Dakar-Fann, Senegal.
Nutrients. 2019 Sep 4;11(9):2093. doi: 10.3390/nu11092093.
infection is common in low-income countries. It has been associated with iron deficiency and reduced efficacy of iron supplementation. Whether infection affects iron absorption from fortified and biofortified foods is unclear. Our objective was to assess whether asymptomatic infection predicts dietary iron bioavailability in women and children, two main target groups of iron fortification programs. We did a pooled analysis of studies in women of reproductive age and preschool children that were conducted in Benin, Senegal and Haiti using stable iron isotope tracers to measure erythrocyte iron incorporation. We used mixed models to assess whether asymptomatic infection predicted fractional iron absorption from ferrous sulfate, ferrous fumarate or NaFeEDTA, controlling for age, hemoglobin, iron status (serum ferritin), inflammation (C-reactive protein), and test meal. The analysis included 213 iron bioavailability measurements from 80 women and 235 measurements from 90 children; 51.3% of women and 54.4% of children were seropositive for . In both women and children, hemoglobin (Hb), serum ferritin (SF), and C-reactive protein (CRP) did not differ between the seropositive and seronegative groups. Geometric mean (95% CI) fractional iron absorption (%), adjusted for SF, was 8.97% (7.64, 10.54) and 6.06% (4.80, 7.67) in positive and negative women ( = 0.274), and 9.02% (7.68, 10.59) and 7.44% (6.01, 9.20) in positive and negative children ( = 0.479). Our data suggest asymptomatic infection does not predict fractional iron absorption from iron fortificants given to preschool children or young women in low-income settings.
在低收入国家,感染很常见。它与缺铁和铁补充剂效果降低有关。但是否感染会影响强化和生物强化食品中铁的吸收尚不清楚。我们的目的是评估无症状感染是否预测妇女和儿童(铁强化计划的两个主要目标人群)的膳食铁生物利用度。我们对在贝宁、塞内加尔和海地进行的、以育龄妇女和学龄前儿童为研究对象的研究进行了汇总分析,这些研究使用稳定的铁同位素示踪剂来测量红细胞铁的掺入量。我们使用混合模型来评估无症状感染是否可以预测硫酸亚铁、富马酸亚铁或 NaFeEDTA 的铁吸收分数,同时控制年龄、血红蛋白、铁状态(血清铁蛋白)、炎症(C 反应蛋白)和测试餐。该分析包括 80 名妇女的 213 个铁生物利用度测量值和 90 名儿童的 235 个测量值;51.3%的妇女和 54.4%的儿童对呈阳性。在妇女和儿童中,血红蛋白(Hb)、血清铁蛋白(SF)和 C 反应蛋白(CRP)在阳性和阴性组之间没有差异。经 SF 调整后的几何平均(95%CI)铁吸收分数(%)分别为 8.97%(7.64,10.54)和 6.06%(4.80,7.67),阳性和阴性妇女(=0.274),9.02%(7.68,10.59)和 7.44%(6.01,9.20)在阳性和阴性儿童(=0.479)中。我们的数据表明,在低收入环境中,对于接受铁强化的学龄前儿童或年轻妇女,无症状感染并不能预测铁强化剂的铁吸收分数。