Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Dębinki St. 7 build. 25, 80-952 Gdańsk, Poland,
Psychiatr Danub. 2019 Sep;31(Suppl 3):520-523.
Major depressive disorder is one of the most important psychiatric issues worldwide, with important prevalence of treatment-resistant depression (TRD). Non-monoaminergic agents are currently in the spotlight. Objective was to explore for information about mechanisms of action of ketamine, its connections with copper and possible importance for TRD treatment. There are at least few possible pathways for ketamine action in depression in which copper and other divalent ions may show a vital role. There is urgent need for more studies to gather information about correlation between ketamine, copper and antidepressive features of these agents.
重度抑郁症是全球最重要的精神疾病之一，其中治疗抵抗性抑郁症（TRD）的患病率很高。目前非单胺能药物备受关注。目的是探讨氯胺酮的作用机制信息，及其与铜的联系和对 TRD 治疗的可能重要性。氯胺酮在抑郁症中的作用至少有几种可能的途径，其中铜和其他二价离子可能起着至关重要的作用。非常有必要进行更多的研究，以收集有关氯胺酮、铜和这些药物抗抑郁作用之间相关性的信息。
