Altaf Afrasyab, Shah Hammad, Salahuddin Momin
Afrasyab Altaf, (MD, PhD, FRCP), Department of Cardiology, Rehman Institute of Medical Sciences, Peshawar, Pakistan.
Hammad Shah, (MBBS), Department of Cardiology, Rehman Institute of Medical Sciences, Peshawar, Pakistan.
Pak J Med Sci. 2019 Sep-Oct;35(5):1349-1354. doi: 10.12669/pjms.35.5.743.
There is very limited data about gender based differences in Acute Coronary Syndrome (ACS) in Asian population. This study was therefore aimed to ascertain gender based differences in clinical and angiographic characteristics and clinical outcomes in patient admitted with ACS.
This was a cross sectional, observational study including patients admitted with diagnosis of ACS. Patients were divided into two groups (Males and Females) and their clinical characteristics were noted. Gender based assessment was done following coronary angiography.
A total of 386 patients were included, with 210 males and 176 females. Anterior wall myocardial infarction (AWMI) was present in 177(45.86%) patients. Mean age was 72.8±12.9 years in females and 66.8±11.2 years in males. Diabetes was present in 38.1% females and 31% males. Patients from rural population were 225(58.3%), while from urban 161(41.7%). Mean ejection fraction was 43.9±7.9% in women and 38.2±8.68% in males.
ACS was more common in males, rural population and AWMI was most common cause. Women were more elderly and had more adverse events as compared to males. Impaired renal dynamics were more commonly observed in males. Women were less aggressively treated with coronary interventions and radial approach was better tolerated regardless of gender.
关于亚洲人群急性冠状动脉综合征（ACS）中基于性别的差异的数据非常有限。因此，本研究旨在确定ACS患者在临床、血管造影特征及临床结局方面基于性别的差异。
这是一项横断面观察性研究，纳入诊断为ACS的患者。患者分为两组（男性和女性），记录其临床特征。冠状动脉造影后进行基于性别的评估。
共纳入386例患者，其中男性210例，女性176例。177例（45.86%）患者存在前壁心肌梗死（AWMI）。女性的平均年龄为72.8±12.9岁，男性为66.8±11.2岁。38.1%的女性和31%的男性患有糖尿病。来自农村地区的患者有225例（58.3%），来自城市的有161例（41.7%）。女性的平均射血分数为43.9±7.9%，男性为38.2±8.68%。
ACS在男性、农村人群中更常见，AWMI是最常见的病因。与男性相比，女性年龄更大且不良事件更多。男性更常观察到肾脏动力学受损。女性接受冠状动脉介入治疗的积极性较低，无论性别如何，桡动脉途径的耐受性更好。
