在相同像素点上进行的双极性基质辅助激光解吸电离成像质谱分析揭示了大鼠小肠中高空间分辨率下的脂质空间定位。
Dual polarity MALDI imaging mass spectrometry on the same pixel points reveals spatial lipid localizations at high-spatial resolutions in rat small intestine.
作者信息
Kaya Ibrahim, Jennische Eva, Lange Stefan, Malmberg Per
机构信息
Department of Chemistry and Molecular Biology , University of Gothenburg , 412 96 , Sweden.
The Gothenburg Imaging Mass Spectrometry (Go:IMS) Platform , University of Gothenburg and Chalmers University of Technology , Gothenburg 412 96 , Sweden . Email:
出版信息
Anal Methods. 2018 Jun 7;10(21):2428-2435. doi: 10.1039/c8ay00645h. Epub 2018 May 3.
Sensitive laser desorption/ionization obtained a sublimation-coated 1,5-diaminonaphthalene (1,5-DAN) matrix allowed dual polarity MALDI-IMS analysis on the same pixel points across the jejunal mucosal region in rat small intestine which yielded high-spatial-resolution (10 μm) ion images of several lipid species correlated with the same histological features.
灵敏激光解吸/电离采用升华涂层的1,5-二氨基萘（1,5-DAN）基质，可在大鼠小肠空肠黏膜区域的相同像素点进行双极性基质辅助激光解吸/电离成像质谱分析，从而获得与相同组织学特征相关的几种脂质的高空间分辨率（10μm）离子图像。
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