Rich Laurie J, Bolookat Eftekhar Rajab, Seshadri Mukund
Department of Oral Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA.
Department of Oral Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA; Department of Radiology-Medical Physics Program, University at Buffalo - Jacobs School of Medicine and Biomedical Sciences, 955 Main Street, Buffalo, NY 14203, USA.
J Oral Biosci. 2019 Dec;61(4):236-241. doi: 10.1016/j.job.2019.08.002. Epub 2019 Sep 3.
The purpose of this study was to apply photoacoustic imaging (PAI), a relatively new imaging method, to non-invasively map neurovascular dynamics in salivary glands. Dynamic PAI with co-registered ultrasound (US) was performed in mice to monitor salivary gland hemodynamics in response to exogenous muscarinic receptor stimulation (pilocarpine) and blockade (atropine). Pilocarpine increased salivary gland oxygen saturation (%sO) within minutes after administration, which was abrogated by atropine. A significant correlation was observed between change in %sO measured by PAI and saliva secretion. PAI is a novel imaging method that can be used for functional assessment of neurovascular dynamics in salivary glands.
本研究的目的是应用光声成像（PAI）这一相对较新的成像方法，对唾液腺中的神经血管动力学进行无创性绘图。在小鼠中进行了联合配准超声（US）的动态PAI，以监测唾液腺对外源性毒蕈碱受体刺激（毛果芸香碱）和阻断（阿托品）的血流动力学反应。毛果芸香碱给药后几分钟内唾液腺氧饱和度（%sO）增加，而阿托品可消除这种增加。通过PAI测量的%sO变化与唾液分泌之间存在显著相关性。PAI是一种可用于唾液腺神经血管动力学功能评估的新型成像方法。
