唾液腺的光声成像。
Photoacoustic imaging of salivary glands.
作者信息
Rich Laurie J, Seshadri Mukund
机构信息
Laboratory for Translational Imaging, Department of Molecular and Cellular Biophysics and Biochemistry, Roswell Park Cancer Institute, Buffalo, New York 14263, USA ; Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Laboratory for Translational Imaging, Department of Molecular and Cellular Biophysics and Biochemistry, Roswell Park Cancer Institute, Buffalo, New York 14263, USA ; Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA ; Department of Head and Neck Surgery, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
出版信息
Biomed Opt Express. 2015 Jul 31;6(9):3157-62. doi: 10.1364/BOE.6.003157. eCollection 2015 Sep 1.
In this work, we utilized photoacoustic imaging (PAI) with co-registered ultrasound (US) to non-invasively assess salivary gland function in vivo. A significant increase in salivary gland oxygen saturation was observed on PAI within minutes after gustatory stimulation of healthy mice reflective of the hyperemic response associated with secretion of saliva. Good correlation was seen between PAI and Doppler sonography. Salivary adenoid cystic carcinomas showed higher oxygen saturation compared to surrounding salivary gland tissue. Our results demonstrate the potential clinical utility of PAI for visualization of salivary gland physiology and pathology.
在这项研究中，我们利用光声成像（PAI）结合配准超声（US）对唾液腺功能进行体内无创评估。在对健康小鼠进行味觉刺激后的几分钟内，通过PAI观察到唾液腺氧饱和度显著增加，这反映了与唾液分泌相关的充血反应。PAI与多普勒超声检查之间存在良好的相关性。与周围唾液腺组织相比，涎腺腺样囊性癌显示出更高的氧饱和度。我们的结果证明了PAI在唾液腺生理和病理可视化方面的潜在临床应用价值。
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