[阿片类药物对粒细胞黏附的影响]
[Effect of opioids on granulocyte adherence].
作者信息
Krumholz W, Weber C, Käbisch S, Hempelmann G
机构信息
Abteilung für Anaesthesiologie und operative Intensivmedizin, Justus-Liebig-Universität Giessen.
出版信息
Anasth Intensivther Notfallmed. 1988 Dec;23(6):313-5.
PMID:3149157
Abstract
The influence of clinically relevant concentrations of fentanyl, alfentanil, morphine, pethidine, and buprenorphine on polymorphonuclear neutrophilic granulocyte (PMN) adherence was investigated in vitro by using nylon fibre columns. Since none of the drugs produced any significant (p less than 0.05) change of adherence, no evidence of opioid mediated increased risk of postoperative bacterial infection could be found.
摘要
采用尼龙纤维柱体外研究了临床相关浓度的芬太尼、阿芬太尼、吗啡、哌替啶和丁丙诺啡对多形核中性粒细胞（PMN）黏附的影响。由于这些药物均未引起黏附的任何显著（p<0.05）变化，因此未发现阿片类药物介导的术后细菌感染风险增加的证据。
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