近年来经典 TRP 离子通道结构研究进展。
Recent progress in structural studies on canonical TRP ion channels.
机构信息
State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China.
State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
出版信息
Cell Calcium. 2019 Nov;83:102075. doi: 10.1016/j.ceca.2019.102075. Epub 2019 Aug 28.
Canonical TRP channels (TRPC) are non-selective cation channels that are involved in various important physiological processes. Currently, the structures of different TRPC ion channel family members are resolved by cryo-EM at resolutions ranging from 2.8 Å to 5.8 Å. These structures reveal the conserved architecture of TRPC ion channels as well as the specific features of each channel subtype. This review focuses on the structural differences in the extracellular portions, transmembrane domains and the cytoplasmic domains of TRPC channels.
经典型瞬时受体电位通道（TRPC）是非选择性阳离子通道，参与多种重要的生理过程。目前，通过低温电镜技术可以解析不同 TRPC 离子通道家族成员的结构，分辨率范围为 2.8 Å 至 5.8 Å。这些结构揭示了 TRPC 离子通道的保守结构以及每个通道亚型的特异性特征。本综述重点介绍 TRPC 通道细胞外部分、跨膜域和细胞质域的结构差异。
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